megavitamin therapy


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The administration of supraphysiologic or in some cases ‘hyper-doses’—up to hundreds of times daily requirement—of vitamins, based on the belief that it will correct an unnamed disorder

megavitamin therapy

The administration of excess or 'hyper-doses' of water-soluble vitamins, either physician-guided–eg, to treat neuropathies, or self-prescribed by health-food advocates. See Decavitamin, Orthomolecular medicine, Vitamin.
Megavitamins, adverse effects  
Thiamin CNS hyperresponsiveness–convulsions, Parkinson's disease–thiamin antagonizes l-dopa, sensory neuropathy–destruction of dorsal axon roots
Niacin/nicotinic acid & niacinamide/nicotinamide Exacerbation of asthma–histamine release, cardiac disease–arrhythmias, GI symptoms, eg nausea, vomiting, diarrhea, anorexia, DM–hyperglycemia, gout–↑ uric acid, liver disease–enzyme leakage, hepatocellular injury, portal fibrosis or massive necrosis, cholestatic jaundice, peptic ulcer disease–histamine release, ↑ acidity, skin disease
Vitamin B6 Paresthesia, headaches, asthenia, irritability
Vitamin C ↑ Iron absorption, possibly iron overload, evoking diarrhea, renal calculus formation and possibly inhibiting the bacteriolytic activity of neutrophils, G6PD deficiency–↑ red cell lysis, megaloblastic anemia–↓ vitamin B12 absorption, nephrolithiasis–oxaluria Diagn Clin Testing 1990; 28:27  

meg·a·vi·ta·min ther·a·py

(meg'ā-vī'tă-min thār'ă-pē)
Large doses of vitamins, minerals, and amino acids that are used as medications to treat physical and psychiatric illnesses.
Synonym(s): orthomolecular medicine.
References in periodicals archive ?
It was these much higher doses that might be needed for full health, and people began to speak of megavitamin therapy.
"Usually the response to nicotinic acid was prompt, often it was spectacular." This breakthrough in the treatment of organic psychoses and schizophrenia was lost for the next decade, until the double-blind studies of Hoffer, Osmond, and Smythies and the birth of megavitamin therapy for schizophrenia.
His pursuit of spirituality through seances and experiments with LSD, as well as megavitamin therapy, ultimately scandalized AA.
Orthomolecular Health Medicine (OHM) is a close-knit group, based in San Francisco, advocating nutrition and megavitamin therapy. The group is one of several orthomolecular groups that champion ideas subscribed to by biochemist Roger Williams, PhD, and Nobel laureate Linus Pauling.