Round eosinophilic cytoplasmic structures suggestive of megamitochondria
were observed in 2 neonates, mild to moderate steatosis and Councilman bodies (apoptosis) in 3, hepatocyte necrosis in 1 (neonate 7) (online Technical Appendix), and mild periportal lymphocytic inflammation in 1 (neonate 2).
Wakabayashi, "Structural changes of mitochondria related to apoptosis: swelling and megamitochondria
formation," Acta Biochimica Polonica, vol.
Intracytoplasmic, intrahepatic inclusions visible on H&E must also prompt the pathologist to consider the following: intracytoplasmic hyaline bodies (IHBs), ground glass inclusions, glycogen bodies, A1AT droplets, and megamitochondria
. The size and morphology of the inclusion, the clinical context of the patient, and, on occasion, use of additional special staining modalities, usually makes the distinction between the various bodies a straightforward process.
The most obvious of these effects are structural changes in the organelle typified by the appearance of megamitochondria
in the livers of patients with ALD (Inagaki et al.
The presence of microvesicular steatosis was significantly associated with histologic indexes denoting severe disease, including higher grades of macrovesicular steatosis, advanced fibrosis, ballooned hepatocytes, megamitochondria, higher NAFLD activity scores, and a diagnosis of nonalcoholic steatohepatitis, she said.
Microvesicular steatosis was three to four times more likely in the presence of ballooning and five times more likely in the presence of megamitochondria, two markers of cell injury.
The presence of microvesicular steatosis was significantly associated with histologic indices that denote severe disease, including higher grades of macrovesicular steatosis, advanced fibrosis, ballooned hepatocytes, megamitochondria
, higher NAFLD activity scores, and a diagnosis of nonalcoholic steatohepatitis.
Free radical-induced megamitochondria
formation and apoptosis.
More advanced injury is associated with Mallory's hyaline and megamitochondria