megamitochondria

megamitochondria

Massively enlarged mitochondria, which are typically seen in alcoholic livers but are also seen in malnutrition, in skeletal muscle with myopathy and in cancer.

Megamitochondria (MG) formation is attributed to free radical formation triggered by ethanol, chloramphenicol and hydrazine, and can be suppressed by free radical scavengers such as alpha-tocopherol and coenzyme Q(10). Continous exposure of cells with MG to free radicals induces apoptosis, a finding which suggests that MG formation is an adaptative process to unfavourable environments at the level of intracellular organelles. Mitochondria try to decrease intracellular reactive oxygen species (ROS) levels by decreasing the oxygen consumption by forming MGs.
References in periodicals archive ?
Round eosinophilic cytoplasmic structures suggestive of megamitochondria were observed in 2 neonates, mild to moderate steatosis and Councilman bodies (apoptosis) in 3, hepatocyte necrosis in 1 (neonate 7) (online Technical Appendix), and mild periportal lymphocytic inflammation in 1 (neonate 2).
Wakabayashi, "Structural changes of mitochondria related to apoptosis: swelling and megamitochondria formation," Acta Biochimica Polonica, vol.
Intracytoplasmic, intrahepatic inclusions visible on H&E must also prompt the pathologist to consider the following: intracytoplasmic hyaline bodies (IHBs), ground glass inclusions, glycogen bodies, A1AT droplets, and megamitochondria.
The most obvious of these effects are structural changes in the organelle typified by the appearance of megamitochondria in the livers of patients with ALD (Inagaki et al.
The presence of microvesicular steatosis was significantly associated with histologic indexes denoting severe disease, including higher grades of macrovesicular steatosis, advanced fibrosis, ballooned hepatocytes, megamitochondria, higher NAFLD activity scores, and a diagnosis of nonalcoholic steatohepatitis, she said.
Microvesicular steatosis was three to four times more likely in the presence of ballooning and five times more likely in the presence of megamitochondria, two markers of cell injury.
The presence of microvesicular steatosis was significantly associated with histologic indices that denote severe disease, including higher grades of macrovesicular steatosis, advanced fibrosis, ballooned hepatocytes, megamitochondria, higher NAFLD activity scores, and a diagnosis of nonalcoholic steatohepatitis.
More advanced injury is associated with Mallory's hyaline and megamitochondria.