megaloblast

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Related to megaloblastic nucleated red cell: microcytic anemia, macrocytic normochromic anemia

megaloblast

 [meg´ah-lo-blast″]
a large, nucleated immature progenitor of an abnormal erythrocytic series, an abnormal counterpart to the normoblast; megaloblasts are present in the blood in certain anemias. adj., adj megaloblas´tic.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

meg·a·lo·blast

(meg'ă-lō-blast'),
A large, nucleated, embryonic type of cell that is a precursor of erythrocytes in an abnormal erythropoietic process observed in pernicious anemia; a megaloblasts four stages of development are as follows: 1) promegaloblast, 2) basophilic megaloblast, 3) polychromatic megaloblast, 4) orthochromatic megaloblast.
See also: erythroblast.
[megalo- + G. blastos, + germ, sprout]
Farlex Partner Medical Dictionary © Farlex 2012

megaloblast

(mĕg′ə-lō-blăst′)
n.
An abnormally large nucleated red blood cell found especially in people having pernicious anemia or certain vitamin deficiencies.

meg′a·lo·blas′tic adj.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

megaloblast

An enlarged erythroblast (erythrocyte precursor) with an enlarged nucleus, which arises in a background of vitamin B12 and/or folic acid deficiency and is characterised by asynchronous nucleocytoplasmic development, and manifest by delayed or incomplete nuclear maturation relative to cytoplasmic development; haemoglobinisation proceeds normally, while nuclear maturation slows as the maturation-dependent methyl precursors—usually provided by vitamin B12 and folic acid—are not present.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

meg·a·lo·blast

(meg'ă-lō-blast)
A large, nucleated, embryonic type of cell that is a precursor of erythrocytes in an abnormal erythropoietic process observed in pernicious anemia; a megaloblast's four stages of development are: 1) promegaloblast, 2) basophilic megaloblast, 3) polychromatic megaloblast, and 4) orthochromatic megaloblast.
See also: erythroblast
[megalo- + G. blastos, germ, sprout]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Megaloblast

A large erythroblast (a red marrow cell that synthesizes hemoglobin).
Mentioned in: Anemias
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.