megaloblast


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megaloblast

 [meg´ah-lo-blast″]
a large, nucleated immature progenitor of an abnormal erythrocytic series, an abnormal counterpart to the normoblast; megaloblasts are present in the blood in certain anemias. adj., adj megaloblas´tic.

meg·a·lo·blast

(meg'ă-lō-blast'),
A large, nucleated, embryonic type of cell that is a precursor of erythrocytes in an abnormal erythropoietic process observed in pernicious anemia; a megaloblasts four stages of development are as follows: 1) promegaloblast, 2) basophilic megaloblast, 3) polychromatic megaloblast, 4) orthochromatic megaloblast.
See also: erythroblast.
[megalo- + G. blastos, + germ, sprout]

megaloblast

/meg·a·lo·blast/ (meg´ah-lo-blast″) a large, nucleated, immature progenitor of an abnormal erythrocytic series; the abnormal form corresponding to the normoblast.megaloblas´tic

megaloblast

(mĕg′ə-lō-blăst′)
n.
An abnormally large nucleated red blood cell found especially in people having pernicious anemia or certain vitamin deficiencies.

meg′a·lo·blas′tic adj.

megaloblast

[meg′əlōblast′]
Etymology: Gk, megas + blastos, germ
abnormally large nucleated immature erythrocyte that develops in the bone marrow in megaloblastic anemias associated with deficiency of vitamin B12, or folic acid. megaloblastic, adj.

megaloblast

An enlarged erythroblast (erythrocyte precursor) with an enlarged nucleus, which arises in a background of vitamin B12 and/or folic acid deficiency and is characterised by asynchronous nucleocytoplasmic development, and manifest by delayed or incomplete nuclear maturation relative to cytoplasmic development; haemoglobinisation proceeds normally, while nuclear maturation slows as the maturation-dependent methyl precursors—usually provided by vitamin B12 and folic acid—are not present.

meg·a·lo·blast

(meg'ă-lō-blast)
A large, nucleated, embryonic type of cell that is a precursor of erythrocytes in an abnormal erythropoietic process observed in pernicious anemia; a megaloblast's four stages of development are: 1) promegaloblast, 2) basophilic megaloblast, 3) polychromatic megaloblast, and 4) orthochromatic megaloblast.
See also: erythroblast
[megalo- + G. blastos, germ, sprout]

Megaloblast

A large erythroblast (a red marrow cell that synthesizes hemoglobin).
Mentioned in: Anemias

megaloblast

a large, nucleated immature progenitor of an abnormal erythrocytic series; megaloblasts are present in the blood in certain anemias. These changes reflect asynchronism in maturation between cytoplasm and nucleus. Observed in folic acid responsive anemias.
References in periodicals archive ?
On investigating her blood picture she was also found to be anemic with megaloblasts on the peripheral smear.
THE diagnosis requires blood tests to look for megaloblasts in your blood and possibly in your bone marrow too, and to measure your levels of vitamin B12 and folic acid.
Megaloblasts are large cells with an increased nuclear/cytoplasmic ratio in which nuclear maturation is delayed, while cytoplasmic maturation is more advanced.