megakaryocyte


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megakaryocyte

 [meg″ah-kar´e-o-sīt″]
the giant cell of bone marrow; it is a large cell with a greatly lobulated nucleus, and is generally supposed to give rise to blood platelets.

meg·a·kar·y·o·cyte

(meg'ă-kar'ē-ō-sīt),
A large cell (as much as 100 mcm in diameter) with a polyploid nucleus that is usually multilobed; megakaryocytes are normally present in bone marrow, not in the circulating blood, and give rise to blood platelets.
[mega- + G. karyon, nut (nucleus), + kytos, hollow vessel (cell)]

megakaryocyte

/mega·karyo·cyte/ (-sīt″) the giant cell of bone marrow containing a greatly lobulated nucleus, from which mature blood platelets originate.megakaryocyt´ic

megakaryocyte

(mĕg′ə-kăr′ē-ō-sīt′, -ə-sīt′)
n.
A large bone marrow cell with a lobulate nucleus that gives rise to blood platelets.

megakaryocyte

[meg′əker′ē·əsīt′]
Etymology: Gk, megas, large, karyon, nut, kytos, cell
bone marrow cell measuring 35 to 160 μm in diameter and having a multilobed nucleus. Megakaryocytes are platelet precursors. Also spelled megacaryocyte. See also platelet. megakaryocytic, adj.

megakaryocyte

A very large cell native to the bone marrow which is the precursor of platelets and the largest (40–100 µm in diameter) normal nucleated haematopoietic cell in the marrow. Megakaryocytes may be relatively small (micromegakaryocytes) and measure 15–30 µm in diameter. The nucleus usually has multiple (8, 16 or 32) overlapping lobes; megakaryocytes with few (2 or 4) lobes may occur in myelodysplasia. Nucleoli are absent, chromatin is coarse, cytoplasm is abundant, stains light blue or pink, and contains numerous purplish-red or pink granules. The N:C ratio is 1:1 to 1:2. Megakaryocytes producing platelets may reveal demarcated granular clumps of platelets extruding/streaming from the margins (platelet budding).

meg·a·kar·y·o·cyte

(meg'ă-kar'ē-ō-sīt)
A large cell with a multilobed nucleus; normally present in bone marrow, not in the circulating blood; gives rise to blood platelets (thrombocytes).
Synonym(s): megalokaryocyte.
[mega- + G. karyon, nut (nucleus), + kytos, hollow vessel (cell)]
Enlarge picture
MEGAKARYOCYTE: (Orig. mag. ×640)
Enlarge picture
MEGAKARYOCYTE

megakaryocyte

(meg?a-kar'e-o-sit?) [? + karyon, nucleus, + kytos, cell]
Large bone marrow cell with large or multiple nuclei from which platelets are derived.
See: platelet; illustrationillustration

megakaryocyte

An unusually large bone marrow cell that releases many small fragments of its CYTOPLASM as the blood PLATELETS essential for clotting (blood coagulation).

Megakaryocyte

A large bone marrow cell with a lobed nucleus that is the precursor cell of blood platelets.

megakaryocyte

large nucleated cell within bone marrow (but not circulating blood), fragments of which form platelets

megakaryocyte

the giant cell of bone marrow; it is a large cell with a greatly lobulated nucleus and gives rise to blood platelets.
References in periodicals archive ?
Enhancement of platelet recovery after myelosuppressive chemotherapy by recombinant human megakaryocyte growth and development factor in patients with advanced cancer.
We have also identified a patient population with a statistically significant poorer outcome to splenectomy, and further research is needed to distinguish patients whose ITP is primarily due to peripheral consumption (the majority of patients with ITP), and who would therefore be likely to benefit from immunosuppression (such as glucocorticoids and splenectomy), from those whose ITP reflects megakaryocyte dysfunction predominantly and who would benefit from TPO agonists.
Furthermore, all patients with the recovery of erythroid or megakaryocyte lineage-specific mRNAs achieved CR or NH (Table 2), although poor mRNA recovery at day 15 or thereafter did not provide an accurate prediction of outcome (Table 2).
Megakaryocytes are also formed during myelopoiesis and these ultimately liberate cytoplasmic contents into the circulation as platelets.
CLT-009, a human Megakaryocyte Progenitor Cell product, would be an alternative treatment option, providing the critical megakayocyte progenitor cellular support to rapidly produce platelets in vivo and shorten the duration of severe thrombocytopenia following chemotherapy treatment.
Megakaryocytes exhibiting variable size and atypia (ballooning and clouding) were seen present in clusters (Figure-1).
Thrombocytopenia cases were associated with reduced number of megakaryocytes, dysmegakaryopoeisis with a slight increase in cases on ART.
Its de novo protein product contributes to cytoplasmic maturation in megakaryocytes and organelle development in platelets, but functions as a negative regulator of megakaryocyte proliferation.
Megakaryocyte growth and development factor ameliorates carboplatin induced thrombocytopenia in mice.
In the current study, the approach involved genetically manipulating such stem cells to become stable immortalized lines of platelet-producing cells called megakaryocyte progenitors.
It has been reported that cytokines such as interleukin-3 and interleukin-6 (IL-6) influence megakaryocyte ploidy and can lead to the production of more reactive and larger platelets (4).