megakaryoblast

(redirected from Megakaryoblastic)

megakaryoblast

 [meg″ah-kar´e-o-blast″]
the earliest cytologically identifiable precursor in the thrombocytic series, which matures to form the promegakaryocyte.

meg·a·kar·y·o·blast

(meg'ă-kar'ē-ō-blast'),
The precursor of a megakaryocyte.
Synonym(s): megacaryoblast

megakaryoblast

The most immature cell of the megakaryocytic series, which is round or ovoid, and large but variably sized (7–35 µm in diameter; those measuring < 15 µm are termed micromegakaryoblasts). The nuclei are round or oval, contain 1+ nucleoli and have a coarse granular pattern; cytoplasm is scant, blue, agranular, often rims the nucleus, occasionally with several small, blunt, budding peripheral protrusions. Megakaryoblasts are normally found only in the marrow, but may be seen in blood smears with myeloproliferative disorders, especially postsplenectomy.

meg·a·kar·y·o·blast

(meg'ă-kar'ē-ō-blast)
The precursor of a megakaryocyte.
References in periodicals archive ?
Tetrasomy 8 as a primary chromosomal abnormality in a child with acute megakaryoblastic leukemia: a case report and review of the literature.
eosinophils; 9872 AMLwith minimal differentiation; 9873 AML without maturation; 9874 AML with maturation; 9891 Acute monoblastic and monocytic leukemia; 9895 AML with myelodysplasia-related changes (multilineage dysplasia); 9896 Acute myeloid leukemia, t(8;21)(q22; q22); 9897 Acute myeloid leukemia with t(9;1 1)(p22;q23);MLLT3-MLL; 9910 Acute megakaryoblastic leukemia; 9920 Therapy-related (acute) myeloid neoplasm (Khwaja et al.
The positive diagnosis was acute megakaryoblastic leukemia (AMKL).
Approximately 1%-2% of children with DS develop acute megakaryoblastic leukemia, mostly before the age of 5 years.
Klusmann, "LincRNAs MONC and MIR100HG act as oncogenes in acute megakaryoblastic leukemia," Molecular Cancer, vol.
Two-year-old Mataese Manuma has a rare cancer called acute megakaryoblastic leukemia.
AML (megakaryoblastic) with t(1; 22)(p13.3; q13.3); RBM15-MKL1
Data were collected in April 2014 and variables occupation and histological type were considered for all leukemia types (acute leukemia, leukemic, basophilic, hairy cells, chronic, Burkitt cells, lymphosarcomatous cells, mast cells, plasma cells, eosinophilic, acute lymphoblastic, chronic lymphoblastic, aleukemic lymphoid, sub-acute lymphoid, lymphoid, acute megakaryoblastic, acute myeloid, aleukemic myeloid, chronic myeloid, sub-acute myeloid, myeloid, acute myelomonocytic, chronic myelomonocytic, acute monocytic, chronic monocytic, aleukemic monocytic, sub-acute monocytic, moncytic, prolymphocytic, acute promyelocytic, sub-acute, leukemia, adult T-cell lymphoma leukemia).
Specific antigens can be demonstrated by flow cytometry that may be used to further subclassify AML, such as CD64 in acute monocytic/monoblastic leukemia and CD61 in acute megakaryoblastic leukemia.
Quesnel, "Successful treatment of imatinibresistant acute megakaryoblastic leukemia with e6a2 BCR/ABL: Use of dasatinib and reduced-conditioning stem-cell transplantation [10]," Leukemia, vol.
Additionally, in 30% of pediatric nonDown syndrome acute megakaryoblastic leukemia (non-DS AMKL), inv(16)(p13.3q24.3) fuses MTG16 to the DNAbinding domain of GLIS2 (ETO2-GLIS2) [91].
Cales, "Ectopic expression of cyclin E allows non-endomitotic megakaryoblastic K562 cells to establish re-replication cycles," Oncogene, vol.