Four patients, 3 of whom had MMIH, had megacystis. Venous thrombosis was detected in the follow-up of 4 patients who were TPN dependent.
Prenatal symptoms can be detected in about 20% of PIPO cases, with megacystis being the most frequently reported indication (11).
The definitions of pyelectasis, hydroureter and megacystis will determine the intensity of investigations and frequency of follow-up, both antenatally and postnatally.
The dilated fetal bladder or megacystis has been defined based on the formula for fetal bladder sagittal length (FBSL) in mm = gestational age in weeks plus 2 (15)
Her family history was significant for a brother with megacystis who had bladder surgery as a child and required catheterization as a toddler.
While hospitalized, an ultrasound at 31 weeks of gestation revealed a fetus measuring greater than the 95th percentile, polyhydramnios, and severe megacystis (Figure 1).
Prenatal findings were a megacystis without malformations, decreasing fetal bladder size accompanied by an increasing amount of fetal ascites, and cyst formation adjacent to the bladder.
One might speculate that the muscle-relaxant effect of benzodiazepines contributed to enlargement of the bladder until a megacystis was present and that opioids induced a spasm of the urinary bladder sphincter leading to urethral obstruction .
microcolon intestinal hypoperistalsis syndrome," Seminars in Pediatric Surgery, vol.
7--15 mm: 20% risk of trisomy; if chromosomally normal 90% chance resolution
Fetal obstructive uropathy without renal dysplasia: a study of the renal findings in 13 cases presenting with megacystis
. J Urol.
[4.] Srikanth MS, Ford EG, Isaacs H Jr, Mahour GH Megacystis
microcolon intestinal hypoperistalsis syndrome: late sequelae and possible pathogenesis.