megabase


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mega-base

A unit of genetic length for DNA (or RNA) fragments equal to 1 million nucleotides (roughly equal to 1 cM).

megabase

(meg′ă-bās″) [ mega- + base],

MB

1. One million paired nucleotides in a DNA sequence.
2. One million unpaired nucleotides in a single-stranded nucleic acid sequence.
3. Informally, any very large fragment of DNA.

megabase

A unit of measurement of the length of a segment of DNA equal to 1,000,000 base pairs. Usually contracted to Mb.

Megabase (Mb)

DNA or RNA of length 106 bases. Used as a unit of length for single-stranded or double-stranded molecules; although Mbp may also be used for the latter.
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base pairs, the number of base pairs in a megabase, by the 300 base
In contrast, a bacterium's genome typically comprises 1 to 4 million base pairs, or megabases (Mb), of DNA, almost all of which encode genes.
Con base en la determinacion de 3,108 ejemplares recolectados en el transcurso de este trabajo, la revision de la Coleccion Galindo (103 ejemplares) y la revision de la megabase MARIPOSA de la Coleccion de la Facultad de Ciencias, UNAM (298 registros provenientes del area de estudio) se integro la lista de la superfamilia Papilionoidea que se distribuye en la Sierra Mazateca, Oaxaca, la cual consta de 460 especiessubespecies, incluidos en seis familias, 19 subfamilias y 246 generos.
After DNA polymerization, the PCR product was purified using the Wizard DNA clean-up System (Promega), sequenced using the automated MegaBase sequencer (Amershan Biotech), and radioactively labeled [([alpha]-[sup.32]P)dCTP] using Oligolabelling Kit (Pharmacia LKB Biotechnology).
Chromosome-specific centimorgan to megabase (cM/Mb) conversion ratios Chromosome Length Length cM/Mb (Mb) (cM) ratio 1 158 166 1.05 2 137 148 1.08 3 121 141.8 1.17 4 121 132.5 1.10 5 121 130 1.07 6 119 134.2 1.13 7 113 125.5 1.11 8 113 124.4 1.10 9 106 110.3 1.04 10 104 118.9 1.14 11 107 129.9 1.21 12 91 117.3 1.29 13 84 118.3 1.41 14 85 127.4 1.50 15 85 110.3 1.30 Chromosome Length Length cM/Mb (Mb) (cM) ratio 16 82 112.4 1.37 17 75 97 1.29 18 66 103.2 1.56 19 64 100.8 1.58 20 72 73.7 1.02 21 72 90.2 1.25 22 61 91.4 1.50 23 53 90 1.70 24 63 85.8 1.36 25 43 62 1.44 26 52 69.8 1.34 27 45 60.9 1.35 28 46 57.3 1.25 29 52 68 1.31 Table 3.
Nevertheless, recent studies have shown that the number of genetic variants is huge, more than 3.5 million variants in the whole genome for a single individual, roughly corresponding to 1,000 variants per megabase pair [4, 5], making the identification of causative variants a task of finding needles in stacks of needles.
Genome sequencers are now available that can sequence one megabase bacterial genomes in a few days.
It does have chromosomes; or at least pulsefield gel electrophoresis generates bands of megabase size that are probably equivalent to chromosomes.
- New York, New York-based biopharmaceutical company Bristol-Myers Squibb (NYSE: BMY) has been notified of US FDA acceptance of its supplemental biologics license application (sBLA) for Opdivo (nivolumab) plus low-dose Yervoy (ipilimumab) for the treatment of first-line advanced non-small cell lung cancer (NSCLC) in patients with tumor mutational burden >=10 mutations per megabase, the company said.
The genomic architecture of cattle [18-21], sheep [22, 23], goats [24], dogs [25, 26], mice [27], and pigs [28, 29] is remarkably similar to that present in Hosa, where there are kilobase and even megabase blocks of polymorphism at which there are retroviral and other indels, segmental duplications, and differences in copy number in addition to nucleotide substitutions [1, 2, 30, 31].
of samples 5 12 Size fraction (pm) 0.2-3 0.1-0.8, 0.8-3 Depth (m) 5 2 Megabase pairs 413 1,940 Mean read length (bp) 368 551 ORFs [(mean [+ or -] SD) %] 81.8 [+ or -] 2.1 69.4 [+ or -] 9.95 Pfams [(mean [+ or -] SD) %] 40.8 [+ or -] 1.5 32.8 [+ or -] 8.9 SRA accession no.