mefloquine


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mefloquine

 [mef´lo-kwin]
an antimalarial agent effective against chloroquine-resistant strains of Plasmodium falciparum and P. vivax; used as the hydrochloride salt.

mefloquine

(mĕf′lə-kwīn′, -kwēn′)
n.
A drug, C17H16F6N2O, used in its hydrochloride form for the treatment and prevention of chloroquine-resistant malaria.

mefloquine

The prophylactic agent of choice for preventing malaria in those travelling to areas with drug-resistant Plasmodium falciparum.
 
Adverse effects
GI tract disturbances, dizziness; at high doses, convulsions, hallucinations.

mefloquine

A drug used to prevent and treat MALARIA. The drug is effective but has been criticized for its neuropsychological side effects which include fatigue, depression, headache, insomnia and distressing dreams. The drug is on the WHO official list. A brand name is Lariam.

Mefloquine

An antimalarial drug that was developed by the United States Army in the early 1980s. Today, malaria resistance to this drug has become a problem in some parts of Asia (especially Thailand and Cambodia).
An antimalarial drug that was developed by the United States Army in the early 1980s. Today, malaria resistance to this drug has become a problem in some parts of Asia (especially Thailand and Cambodia).
Mentioned in: Malaria
References in periodicals archive ?
Table 2--Concentrations of mefloquine determined in the plasma and erythrocytes of children and adults with uncomplicated falciparum malaria.
It was found that amplification of the copy number of the wild form of pfmdr-1 gene accounts for half of the recrudescence and treatment failure that occur after having selection pressure induced by mefloquine (MQ), lumefantrine (LM), and artemisinin (ART).
In the 'adverse event report' by the Food and Drug Agency, the author states, of a subject who killed 17 civilians (the same number Bales was initially believed to have killed): "This patient was administered mefloquine in direct contradiction to US military rules that mefloquine should not be given to soldiers who had suffered TBI due to its propensity to cross blood brain barriers inciting psychotic, homicidal or suicidal behaviour.
Randomised trial of artesunate and mefloquine alone and in sequence for acute uncomplicated falciparum malaria.
Mefloquine can also be an option in countries of susceptible malaria strains.
The US military administered the drug despite Pentagon knowledge that mefloquine caused severe neuropsychiatric side effects, including suicidal thoughts, hallucinations and anxiety.
Quinolinemethanol drugs (mefloquine and quinine) are us ed in treatment of malarial due to their esquizonticide effect (Jaime and Williams, 1988).
The study concerned versions of such widely used and trusted medications as sulfadoxine-pyrimethamine, amodiaquine, mefloquine, artesunate, artemether, dihydroartemisinin and artemether-lumefantrine fixed-dose combinations.
Strains of falciparum parasites have also developed resistance to sulphadoxine-pyremethamine (Fansider) and mefloquine in many parts of the world.
Mefloquine appears to be the agent most associated with an increased risk of psychiatric morbidity (Wooltorton 2002).
Mefloquine and doxycycline must be taken for 4 weeks after returning from the malaria area