medulloblastoma


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medulloblastoma

 [mĕ-dul″o-blas-to´mah]
a brain tumor composed of medulloblasts.

me·dul·lo·blas·to·ma

(med'yŭ-lō-blas-tō'mă), [MIM*155255]
`A tumor consisting of neoplastic cells that resemble the undifferentiated cells of the primitive medullary tube; medulloblastomas are usually located in the vermis of the cerebellum, and may be implanted discretely or coalescently on the surfaces of the cerebellum, brainstem, and spinal cord; they comprise approximately 3% of all intracranial neoplasms, and occur most frequently in children; the neoplastic cells are compactly arranged, rounded or ovoid, with hyperchromatic nuclei and relatively scant cytoplasm, and lie in small and poorly defined groups, or, occasionally, in a pseudorosette pattern (Homer-Wright rosette). A type of primitive neuroectodermal tumor.

medulloblastoma

Primitive neuroectodermal tumor Neurology A malignant brain tumor that comprises ±14 of intracranial tumors in children and adolescents; it is most common at the midline of the cerebellum, and on the roof of 4th ventricle Clinical Presents with N&V, headache, ataxia, papilledema, nystagmus, irritability, lethargy, cranial nerve palsy, dizziness, altered vision Prognosis 2 yr-survival after relapse is 46% in those treated with salvage chemotherapy or RT, 0% in untreated Pts. See Brain tumor. Cf Glioblastoma.

me·dul·lo·blas·to·ma

(mĕ-dŭl'ō-blas-tō'mă)
A tumor consisting of neoplastic cells that resemble the undifferentiated cells of the primitive medullary tube; medulloblastomas are usually located in the vermis of the cerebellum, comprise approximately 3% of all intracranial neoplasms, and occur most frequently in children.

medulloblastoma

A malignant brain tumour, most commonly affecting children and usually occurring in the CEREBELLUM or in the nearby roof of the FOURTH VENTRICLE.
References in periodicals archive ?
Swifty Foundation's three main priorities are increasing post-mortem brain tissue donations, creating more collaboration in the field of childhood cancer research and raising the survival rate of recurrent medulloblastoma in children.
Medulloblastoma harbor somatic mitochondrial DNA mutations in the D.loop region.
The news has been welcomed by the parents of Olly McKenna who was diagnosed with medulloblastoma less than a year ago and has battled back to health.
However, brainstem glioma was the second most common histological type (17.6%), which diverges from a classic study on the subject, which shows the medulloblastoma in the second position.
Medulloblastoma forms a difficult to treat malignancy, due to its aggressive and fast growth.
"Medulloblastoma occurs in 10%-20% of patients with basal cell nevus syndrome and can be the presenting sign.
Medulloblastoma in childhood: new biological advances.
On the other hand 15 (30%) patients from infratentorial group were found to have three characteristic type of tumors including medulloblastoma, ependymoma and astrocytoma.
grade 3 and 4 astrocytomas (67% and 39.4%, respectively), medulloblastoma and primitive neuroectodermal tumours (50%).
Zhu, "Adult medulloblastoma: clinical characters, prognostic factors, outcomes and patterns of relapse," Journal of Neuro-Oncology, vol.
The histological features seen in our case did not show the classical architectural pattern of Medulloblastoma. On the contrary, there were angiocentric arrangement and peculiar perivascular accentuation (Figure 2(a)) commonly seen in CNS lymphoma and other glial tumors such as ependymomas.
Among 50 cases in the present study, Meningiomas accounted for 18 cases, followed by Astrocytomas accounting for 17 cases and Schwannoma and Tuberculomas with 3 cases each ,2 cases of Pituitary macroadenoma, 2 cases of Craniopharyngioma, one case of oligoastrocytoma, oligodendroglioma/Subependymoma, secondaries, medulloblastoma each (Table 2).