Uncertainty about the significance of serum testosterone determinations stem from the finding that they are a poor reflection of prostate tissue androgen levels, (2) but perhaps more confounding is the realization that following medical castration
, there is a decrease of 94% in serum testosterone levels while intraprostatic testosterone and dihydrotestosterone remain at 20-30% of pre-castration levels.
Castrate levels of serum testosterone can be achieved either by medical castration
Surgical or medical castration
is the gold standard of therapy in patients with metastatic carcinoma [2,3] and may be required in a number of patients who are initially treated with radical surgery or radiotherapy.
Also of note is that this is the use of an antiandrogen as opposed to medical castration
lifelong; that's something that makes this trial somewhat unique.
Currently the main treatment option available to patients in Japan is medical castration
, however prostate cancer can still progress in many patients because androgens are produced in other tissues.
The trial with 60 healthy volunteers found that temporary medical castration
was achieved in subjects given either 1,000 mg or 1,500 mg of the drug, called GTx-758, but not a lower dose of 600 mg.
In addition, we show that recent efforts to refer to sexual impotence more narrowly as erectile dysfunction fail to separate the metaphorical from the physical meaning of impotence, and do not solve the problem of the shame associated with medical castration
But the challenge of androgen ablation therapies via surgical or medical castration
, with/without anti-androgenic agents, is that most cancers still progress to the hormone refractory stage.
A form of medical castration
was developed which lowers testosterone levels to such a degree it has an effect throughout the body and on the libido.
When used in combination with medical castration
, abiraterone acetate augments cytoreduction in patients with localized high-risk prostate cancer.
TORONTO -- Prostate cancer patients considering medical castration
need to be told to expect diminished muscle mass and strength along with increased body fat, Dr.