Uncertainty about the significance of serum testosterone determinations stem from the finding that they are a poor reflection of prostate tissue androgen levels, (2) but perhaps more confounding is the realization that following medical castration
, there is a decrease of 94% in serum testosterone levels while intraprostatic testosterone and dihydrotestosterone remain at 20-30% of pre-castration levels.
Castrate levels of serum testosterone can be achieved either by medical castration
Surgical or medical castration
is the gold standard of therapy in patients with metastatic carcinoma [2,3] and may be required in a number of patients who are initially treated with radical surgery or radiotherapy.
By day 28, mean testosterone concentration was suppressed below castrate levels to 17.6 ng/dL, and the suppression rate was 98.5% (135 out of 137 subjects achieved medical castration
Our patient opted for medical castration
. The decrease in size of the parietal swelling on CT scan and lower serum PSA levels are indicators of a good biological response of the disease.
"Also of note is that this is the use of an antiandrogen as opposed to medical castration
lifelong; that's something that makes this trial somewhat unique."
Taking into regard the heinous nature of this crime there is nothing wrong in suggesting to bring a bill for "Medical Castration
Surgical castration is permanent but "medical castration
" provides men the potential advantage of receiving therapy intermittently.
The trial with 60 healthy volunteers found that temporary medical castration
was achieved in subjects given either 1,000 mg or 1,500 mg of the drug, called GTx-758, but not a lower dose of 600 mg.
In addition, we show that recent efforts to refer to sexual impotence more narrowly as erectile dysfunction fail to separate the metaphorical from the physical meaning of impotence, and do not solve the problem of the shame associated with medical castration
. Society's failure to recognize that castration is still common adds to the stigma of those who are emasculated for medical reasons.
Testosterone suppression ("medical castration
") is a major treatment strategy in advanced prostate cancer.