mediator complex

mediator complex

coactivation proteins involved in RNA polymerase transcription of DNA segments.

mediator complex

A multimeric protein complex that is required for DNA-binding activation and regulated transcription of nearly all RNA polymerase II-dependent genes. The mediator complex (MC) serves as a bridge, conveying information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. It is recruited to promoters by direct interactions with regulatory proteins, and it serves as a scaffold for assembling a functional pre-initiation complex with RNA polymerase II and general transcription factors.

me·di·a·tor com·plex

(mē'dē-ā-tōr kom'pleks)
Coactivation proteins involved in RNA polymerase transcription of DNA segments.
References in periodicals archive ?
Mediator complex was first identified from yeast S.
Through the systematic dissection of functional domains of scMed6p, we identified three distinct domains of scMed6p required for its essential function: one N-terminal region ([DELTA]2, amino acids 33-42) might be involved in Mediator association and/or protein stability, and the second ([DELTA]5, amino acids 125-134) and third ([DELTA]6, amino acids 157-166) regions have a role in postrecruitment activity of Mediator complex, such as signal-relay or conformational changes.
He will also evaluate inhibitors of CDK8, a member of the transcriptional mediator complex for their activity and study the mechanism of action in the context of RUNX1 and/or STAG2 mutations.
Rapamycin treatment for 12 weeks also increased expression of cardiac Mediator Complex 13 (MED13) which is known to improve whole body metabolism.
Csm3, tof1, and mrc1 form a heterotrimeric mediator complex that associates with DNA replication forks.