medial calcific sclerosis

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an induration or hardening, especially of a part from inflammation, or in disease of the interstitial substance. The term is used chiefly for such a hardening of the nervous system due to hyperplasia of the connective tissue or for hardening of the blood vessels. Called also induration. adj., adj sclerot´ic.
amyotrophic lateral sclerosis see amyotrophic lateral sclerosis.
arteriolar sclerosis arteriolosclerosis.
disseminated sclerosis multiple sclerosis.
familial centrolobar sclerosis a progressive familial form of leukoencephalopathy marked by nystagmus, ataxia, tremor, parkinsonian facies, dysarthria, and mental deterioration.
focal glomerular sclerosis focal segmental glomerulosclerosis.
glomerular sclerosis glomerulosclerosis.
hippocampal sclerosis loss of neurons in the region of the hippocampus, with gliosis; sometimes seen in epilepsy.
lateral sclerosis a form seated in the lateral columns of the spinal cord. It may be primary, with spastic paraplegia, rigidity of the limbs, and increase of the tendon reflexes but no sensory disturbances, or secondary to myelitis, with paraplegia and sensory disturbance.
medial calcific sclerosis (Mönckeberg's sclerosis) Mönckeberg's arteriosclerosis.
multiple sclerosis see multiple sclerosis.
systemic sclerosis systemic scleroderma.
tuberous sclerosis a congenital heredofamilial disease, transmitted as an autosomal dominant trait, characterized principally by the presence of hamartomas of the brain (tubers), retina (phakomas), and viscera, mental retardation, seizures, and adenoma sebaceum, and often associated with other skin lesions.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

medial calcific sclerosis

A type of dystrophic calcification in which calcium is deposited in the tunica media of arteries.

Clinical findings
Medial cystic sclerosis is usually asymptomatic, but may be associated with atherosclerosis, hypertension, diabetes and chronic kidney disease. Areas affected are “pulseless” due to the calcified encasement; areas beyond the sclerosis have a “bounding” pulse.

Affected medium-sized arteries in the upper and lower limbs have linear calcifications, resulting in a so-called pipestem appearance.
Uncertain; an array of calcium-regulating proteins have been implicated, including osteopontin, osteoprotegerin, matrix GLA protein, fetuin-A, receptor activator of NF-kappa-B, receptor activator of NF-kappa-B ligand and TNF-related apoptosis-inducing ligand.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Calciphylaxis or calcific uremic arteriolopathy (CUA) is a rare and severe disorder characterized by systemic medial calcification of arteries and arterioles that leads to skin and soft tissues ischemic necrosis with the development of ulcers (1).
Medial calcification, or Monckeberg's arteriosclerosis, is the pathological deposition of calcium-phosphate mineral along the elastic fibers in the middle layer of arteries and is associated with chronic kidney disease (CKD), diabetes, and ageing.
Calciphylaxis, or calcific uremic arteriolopathy, is a rare but morbid condition resulting from medial calcification of arterioles and leading to ischemia and resultant necrosis [1, 2].
Leaf et al., "Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin," KidneyInternational, vol.
The pathologic diagnostic criteria for calciphylaxis utilized at the Mayo Clinic require skin biopsy evidence of medial calcification and intimai fibroplasia of pannicular arterioles with cutaneous necrosis.
To quantify vascular medial calcification, the aortic roots (from the aortic opening to 0.5 cm from the opening section of the aorta) were separated and stored in 4% paraformaldehyde for H&E histopathological staining.
Medial calcification is an abnormality that produces stiffening of the arteries resulting in increased pulse pressure, increased pulse wave velocity, and increased systolic blood pressure.
It has been shown that lack of osteoprogerin in rats develops osteoporosis and medial calcification in the aorta.12
###Ectopic Calcifications in Different Tissues16###Vascular calcification (Monckeberg's sclerosislinear medial calcification) especially involving metatarsal arteries.
Of note, only 27% of aortas from LA-treated rabbits exhibited any measurable (> 1% area) medial calcification at histology (P = NS vs controls).
Recent evidence suggests that medial calcification in diabetes is an active, cell-mediated process, similar to that observed in patients with end stage renal disease [23,24].

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