mecillinam

mecillinam

An extended-spectrum penicillin that is only active against gram-negative bacteria. It is not available in the USA.

Indications
Urinary tract infections, typhoid, paratyphoid fever.
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References in periodicals archive ?
Inhibition of lateral wall elongation by mecillinam stimulates cell division in certain cell division conditional mutants of Escherichia coli.
We tested mecillinam, amoxicillin/clavulanic acid, piperacillin/tazobactam, cefoxitin, cefotaxime, ceftazidime, cefepime, aztreonam, meropenem, gentamicin, tobramycin, amikacin, nalidixic acid, ciprofloxacin, trimethoprim, cotrimoxazole, nitrofurantoin, and tigecycline.
Susceptibility of community Gram-negative urinary tract isolates to Mecillinam and other oral agents.
M2 PHARMA-May 17, 2018-Utility Therapeutics Licenses US Rights to Mecillinam, Pivmecillinam from LEO Pharma
Two-thirds of women with uncomplicated urinary tract infection treated symptomatically with ibuprofen 400 to 600 mg three times a day for three days recovered without use of antibiotics in three separate randomized clinical studies against ciprofloxacin, mecillinam, and fosfomycin.
Assay of ethambutol hydrochloride, mecillinam and levamisole hydrochloride tablets by linear titration," Zhongguo.
Kahlmeter, "A 10- year study of the consumption of quinolones trimethoprim and mecillinam in relation to the development of antimicrobial resistance in a large number of species," in Proceeding of European Congress of Clinical Microbiology and Infectious Diseases, Poster 417, Amsterdam, Netherlands, July 2002.
"With this setup, we could detect the differential growth rate between treatment and reference populations in 3 min for ciprofloxacin, levofloxacin, mecillinam, nitrofurantoin, and trimethoprim-sulfamethoxazole; 7 min for amoxicillin-clavulanate and doripenem; 9 min for fosfomycin; and 11 min for ampicillin based on 99.9% confidence intervals," wrote Ozden Baltekin and his coauthors.
Harding et al., "A Canadian national surveillance study of urinary tract isolates from outpatients: comparison of the activities of trimethoprim-sulfamethoxazole, ampicillin, mecillinam, nitrofurantoin, and ciprofloxacin," Antimicrobial Agents and Chemotherapy, vol.
All isolates were resistant to cefamandole, ampicillin, cloxacillin, colistin, mecillinam ciprofloxacin and tetracycline ,while all of isolates were sensitive to Azithromycin ,penicillin G and novobiocin (Table 3).
Mecillinam is a novel [beta]-lactam antibiotic that is active against many members of family Enterobacteriaceae.