mechlorethamine


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mechlorethamine

 [mek″lor-eth´ah-mēn]
an alkylating agent that produces interstrand and intrastrand cross-linkages in DNA with resultant miscoding, breakage, and failure of replication. Used primarily for the treatment of disseminated hodgkin's disease, especially in the MOPP treatment regimen, and for other lymphomas, including mycosis fungoides; administered intravenously as the hydrochloride salt. Called also nitrogen mustard.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

mechlorethamine

A nitrogen mustard derivative which binds to DNA, crosslinking both strands to prevent its replication.

Global village
Mechlorethamine was first developed as a chemical weapon.

Oncology
A nitrogen mustard alkylating agent used for managing lymphomas; part of MOPP.
 
Adverse effects
Nausea, vomiting, marrow suppression, skin vesiculation at injection site.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

mechlorethamine

Oncology An alkylating nitrogen mustard chemotherapeutic used for lymphomas Adverse effects GI Sx, BM suppression, skin vesiculation at injection site. See MOPP regimen.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

ni·tro·gen mus·tards

(HN) (nī'trŏ-jĕn mŭs'tărdz)
A group of toxic chemicals developed for use as chemical-warfare agents.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
The in vivo genetic activity profile of the monofunctional nitrogen mustard 2-chloroethylamine differs drastically from its bifunctional counterpart mechlorethamine. Carcinogenesis 21:1859-1867.
Flare: a localized, self-limiting hypersensitivity response, usually to anthracycline or mechlorethamine
ProMACE-MOPP-prednisone + methotrexate + adriamycin (doxorubicin) + cyclophosphamide cytoxan) + etoposide (VP-16) + mechlorethamine + oncovin (vincristine) + procarbazine + prednisone.
Valchlor gel has been formulated as a once-daily, topical application that dries on the skin, and it is the only FDA-approved formulation of mechlorethamine.
Mechlorethamine is a chemotherapeutic agent that has previously been approved for intravenous treatment of the most common type of CTCL, namely mycosis fungoides.
The basis for the approval came from the positive results from a randomised, observer-blinded, non-inferiority pivotal trial that compared Valchlor to a pharmacycompounded mechlorethamine preparation in patients with stage IA-IIA MF-type CTCL.
The drug is known in the USA as mechlorethamine gel and is currently undergoing review by the US drug regulator for early stage (stages I-IIA) mycosis fungoides, a type of CTCL.
M2 PHARMA-October 4, 2011-FDA accepts for filing Yaupon's mechlorethamine gel NDA(C)2011 M2 COMMUNICATIONS
4 October 2011 - US Yaupon Therapeutics Inc said on Tuesday that the New Drug Application (NDA) for its propriety gel formulation of mechlorethamine hydrochloride has been accepted for filing by the US Food and Drug Administration (FDA).
The firm is seeking US approval of its mechlorethamine gel for the treatment of early stage (stages I-IIA) mycosis fungoides, the most common type of Cutaneous T-Cell Lymphoma (CTCL).
Yaupon's mechlorethamine gel has been granted FDA Orphan Drug status, the company said.