Two phase IIa studies, in patients with IPF and a mechanistic study
in dSSc respectively, are on track to commence in the second half of 2019.
Bristol-Myers announced data from a Phase 4 mechanistic study
exploring differences in the cellular and molecular mechanisms by which Orencia and another treatment, adalimumab, interfere with disease progression in moderate-to-severe early rheumatoid arthritis, or RA, patients seropositive for certain autoantibodies.
A mechanistic study
in a different group of psoriasis patients provided a likely explanation for the long relapse-free period seen off therapy in some patients in the extension study.
In an interesting mechanistic study
entitled "CLOCK Promotes Endothelial Damage by Inducing Autophagy through Reactive Oxygen Species" authors try to establish a connection between ROS, autophagy, and endothelial dysfunction.
Laurent Fischer, MD, chief executive officer of Tobira, said, 'Completion of enrolment in this mechanistic study
marks another milestone for Tobira as we explore the full potential of CVC.
However, deaths caused by heart failure were balanced between those on saxagliptin and those on placebo, and no possible mechanism for the HF finding could be identified, according to AstraZeneca, which is planning a mechanistic study
to evaluate the effects of saxagliptin on volume, neurohormonal changes, and cardiac function.
Our current findings strongly support the use of an anti-Wip1 drug for cancer treatment in order to reduce a high frequency of mutations in the genome, which is one of the main drivers of tumour relapses." Prof Hong Wan Jin, Executive Director of IMCB, said, "Dmitry has been the pioneering driver in the mechanistic study
of Wip1 phosphatase, and this discovery is monumental in providing novel understanding on the role of Wip1 in cancer at the genomic and systems levels.
A mechanistic study
(one that looks to elucidate a mechanism of action for a drug or product in a biological system), does not always translate to how the product will actually work in a real human being.
The topics include analyzing the mineralogical component of palm oil fuel ash with or without unburned carbon, the effect of different gloss firing temperature on the crystallization of zinc-based crystal glaze, forming a titanium carbide reinforced copper matrix composite by an in situ process, synthetic hydrotalcite prepared from a modified combustion method using glucose as fuel, the formation and mechanistic study
of self-ordering zirconium oxide nanotubes by anodic oxidation, and the characterization and phase evolution of cordierite based glass synthesis from pure oxide and minerals.
ON THE DEGRADATION OF GASOLINE OXYGENATES BY ULTRASONIC IRRADIATION.
(60) Mechanistic study
on the role of para-aramid short fibers in rubber to brass adhesion.