suicide substrate

(redirected from mechanism-based inhibitor)

su·i·cide sub·strate

a competitive inhibitor that is converted to an irreversible inhibitor at the active site of the enzyme.
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In the September issue of Nature Medicine, they explain that this class of drugs, which they call "mechanism-based inhibitors," trick the bacterial cells into thinking they are nutrients and absorbing them.
The group focused initially on the design of mechanism-based inhibitors, but embraced structure-based strategies and the full gamut of modern drug strategies which have enzymes as targets.

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