mechanism of action


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mechanism of action

(1) The manner in which a therapeutic agent acts, which includes blocking of receptors, enzymes, stimulating hormone production, etc. 
(2) The physiologic or biochemical processes within the body that are affected by a drug’s action, producing a given response.

mechanism of action

The means by which a drug exerts its effects on cells or tissues. It may have specific binding sites, receptor activation, enzymatic activity, or solubility.
See also: mechanism
References in periodicals archive ?
Mechanism of Action based reports is the key for them,” said Ms Mridhu Verma, Analyst at DelveInsight.
"This unique mechanism of action appears to significantly limit side effects associated with marketed drugs," he added.
(6,10) Zonisamide may also have a mechanism of action that is similar to bipolar agents, and may therefore be an effective second-line choice.
This lack of elimination of bactericidal action suggests that these agents possess a secondary bactericidal mechanism of action that does not depend on the synthesis of protein and RNA, and that may be active when the bacteria are in a nonreplicating state (46).
This report provides comprehensive information on the therapeutic development for Hairy Cell Leukemia, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases.
This report provides comprehensive information on the therapeutic development for Haemophilus influenzae Type B Infections, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases.
Good, Trevi's President and Chief Executive Officer, said, "Since receiving Series A financing 18 months ago, the Company has generated compelling proof of concept safety and efficacy data for Nalbuphine ER in itch, including most recently in uremic pruritus.We continue to believe that the dual mechanism of action of nalbuphine is uniquely suited to treating many itch conditions."
The new molecule inhibits the activity of pain-transmitting neurons, using a novel mechanism of action, BioLineRx added.
Therefore, the mechanistic basis for the in vitro assays has been developed through basic research, either to characterize the mechanism of action of a specific toxicant, or to understand the basic biology of a system.
Benefits Understanding mechanism of action of anticonvulsants (1-8) should help a prescriber match the best drug action to the specific psychiatric disorder of a given patient
These patented compounds are potent tumor growth inhibitors and appear to have a unique mechanism of action. Given their very promising anti-tumor activity in xenograft models, they show early signs of being an exciting novel class of anti-tumor agent.
Characterization of a small molecule HIV-1 attachment inhibitor BMS-488043: virology, resistance and mechanism of action. [abstract 534]