The inhibitory effect of CCL3 on BzATP-induced release of IL-1jS by U937 cells was indeed sensitive to mecamylamine
(100, wM; p = 0.001, n = 5 versus n = 9), a general nAChR antagonist.
In the hot plate test the oil inhalation induced an analgesic activity which was inhibited by naloxone, atropine, and mecamylamine
before treatment, thus supporting the involvement of both opioidergic and cholinergic pathways .
(a nicotine antagonist) for smoking cessation.
These results were identical to those obtained by administering a nicotinic cholinergic receptor antagonist (mecamylamine
8) The learning ability of the rats infused with GGR-41 was remarkably reduced to the same extent as seen in the rats given mecamylamine
, a nicotinic cholinergic receptor antagonist.
One RCT (N=48) comparing nicotine patches plus the nicotine antagonist mecamylamine
with patches plus placebo found improved abstinence rates at 6 and 12 months; a larger RCT didn't support these findings.
Human laboratory studies have shown that mecamylamine
, a nonselective nAChR antagonist approved for hypertension, can reduce alcohol preference and the stimulating effects of alcohol in healthy study participants (Blomqvist et al.
The study authors were also able to undo some harmful effects of nicotine in mice to some extent by treating them with the nicotine antagonist mecamylamine
, a drug that blunts the action of nicotine.
Intensive Intervention for Toddlers with Autism; A Pilot study of Daytrana TM in Children with Autism Co-Morbid for Attention Deficit Hyperactivity Disorder (ADHD) Symptoms; Minocycline to Treat Childhood Regressive Autism; Effectiveness of Atomoxetine in Treating Attention Deficit Hyperactivity Disorder Symptoms in Children and Adolescents with Autism; Comparing Parent-Implemented Interventions for Toddlers with Autism Spectrum Disorders and A Pilot Trial of Mecamylamine
for the Treatment of Autism are just few clinical studies and intervention regimen on autism currently funded by the United States National Institute of Health (http://clinicaltrials.gov).
VIENNA -- Mecamylamine
, an old, rarely prescribed, truly obscure antihypertensive agent, may be favorably reincarnated as an antidepressant with a completely novel mechanism of action--and vastly greater potential use.