measurable disease

measurable disease

A condition characterised by a lesion or tumour that can be measured in size, which is used to evaluate response to treatment.

measurable disease

Oncology A condition characterized by a lesion or tumor that can be measured in size, information which is used to evaluate response to treatment. See Occult disease.

measurable disease

(mezh′ŭr-ă-bĕl)
The amount of tumor or infection that can be detected in the body by conventional means. It may be equal to or less than the total body disease burden. Treatment of detectable disease may result in durable disease remission or apparent cure even when some cancerous or infected cells remain undetected in the body.
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In a prespecified exploratory analysis of patients in the ITT population with measurable disease at baseline showed a tumor response was reported in 18% of patients on rucaparib compared to 8% of patients on placebo, including 7% in the rucaparib group who achieved a complete remission.
In patients with visceral metastases and measurable disease, the overall response rate (ORR) in patients who received Kisqali plus endocrine therapy compared to endocrine therapy alone was 53% vs 40% (MONALEESA-2), 50% vs 38% (MONALEESA-7) and 48% vs 31% (MONALEESA-3).
From patients with measurable disease according to the Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 (n = 42), all radiological images were reviewed, and disease evolution was assessed applying the very same criteria.
Objective response rate in patients with measurable disease was 52.7% (95% CI, 46.6-58.9) in the ribociclib plus letrozole arm and 37.1% (95% CI, 31.1-43.2) in the placebo plus letrozole arm, the Food and Drug Administration said in a written statement.
Applying data from pulmonary colorectal metastasis to thymic metastasis, an attempt to render the patient free of obvious measurable disease should be made, if possible.
This triple combination study is assessing the safety and effectiveness of the company's DPX-Survivac, along with Incyte's investigational oral indoleamine 2,3-dioxygenase 1 (IDO1) enzyme inhibitor, epacadostat, and low-dose cyclophosphamide in patients with recurrent ovarian cancer who have measurable disease.
Twenty patients had measurable disease, with a median of 1 prior chemotherapy regimens and a median PSA of 255.8 ng/ml.
Post- treatment imaging showed regression of all disease sites with no measurable disease. Patient was in remission when last seen in October 2013.
We only included patients with clear cell histology and measurable disease. For each patient, information on the date of nephrectomy, initial prognostic class based on Memorial Sloan Kettering Cancer Centre (MSKCC) criteria, the type and length of the first-, second- and third-line therapy were collected.[sup.8] Two sequences of therapy were considered: (1) SU followed by EV (SU-EV) and (2) SU followed by TM (SU-TM).
Patients with tumors assessed by CT scan ([greater than or equal to] 10 mm) or by ultrasonography ([greater than or equal to] 20 mm) were classified as measurable disease. Nonmeasurable disease included cystic lesions and ascites.
Eligible patients must have been treated initially with surgery, had a response to first-line platinum- and taxane-based therapy, and have relapsed as defined by the presence of measurable disease. Patients must have also relapsed between 6 and 24 months from the time of completion of their first-line platinum and taxane therapy and been eligible for carboplatin and taxane treatment.
He is a Fellow of the Obesity Society and a founder of founder and developer of Prescriptfit, a medical nutrition therapy plan which produces weight loss and measurable disease improvement.