Person B injected the drugs and observed the response heart rate (HR) and

mean arterial pressure (MAP)) and person C who was an experienced qualified anaesthesiologist, intubated the patient.

In unique regression models (models 10 to 12), increased frequency of preventive care was associated with lower levels of sICAM-1 independent of the effects of the demographic variables and after controlling for BMI, total cholesterol or

mean arterial pressure.

Physiological parameters Before (0 min) During (15 min) MAP (mmHg) 93 90 (14, 67-117) (16, 67-124) MPaw (cmH20) 11 13 (2,8-13) (2,8-18) HR (bpm) 92 92 (18, 56-125) (18, 57-124) VE (1/min) 9.8 9.8 (2.5,6-18) (3.7,5-22) VT (ml) 557 1337 (88,447-750) (430, 418-2569) RR (bpm) 17 8 (3, 13-24) (3,4-15) Physiological parameters During (30 min) After (35 min) MAP (mmHg) 89 91 (17, 57-120) (15, 61-117) MPaw (cmH20) 13 11 (3,8-19) (2,7-15) HR (bpm) 93 92 (18, 61-122) (17, 59-125) VE (l/min) 8.9 9.5 (3.3,5-19) (2.6, 6-16.5) VT (ml) 1330 562 (452, 551-2718) (90,447-769) RR (bpm) 7 17 (3,4-14) (3, 12-25) MAP =

mean arterial pressure; MPaw = mean airway pressures; HR = heart rate; V'E = minute ventilation; VT = tidal volume; RR = respiratory rate.

The experimental groups did not differ with respect to blood pressure at baseline as measured via Riva-Rocci (systolic blood pressure: t(78) = 0.23, p = .82, diastolic blood pressure: t(78) = 1.18, p = .24,

mean arterial pressure: t(78) = 0.59, p = .56), heart rate at baseline (t(78) = 0.55, p = .58) and in terms of Body Mass Index (t(78) < 0.001, p = .99).

There was a statistically significantfaii in the heart rate, systolic, diastolic and

mean arterial pressure (p-0.000) during infusion of dexmedetomidine.

Hypotension was treated with IV phenylephrine 50-100mcg boluses aiming to restore

mean arterial pressure within 20% of baseline values.

Patient characteristics and baseline data PCV VCV (n=30) (n=30) Age (years) 44[+ or -]14 48[+ or -]14 Gender: male 15 15 female 15 15 Weight (kg) 81[+ or -]13 78[+ or -]16 Height (cm) 175[+ or -]11 174[+ or -]9 BMI (kg/[m.sup.2]) 26[+ or -]3 25[+ or -]4 HR (beats/min) 84[+ or -]15 85[+ or -]14 MAP (mm Hg) 108[+ or -]14 107[+ or -]12 SpO2 (%) 98[+ or -]1 98[+ or -]1 Values are mean [+ or -] standard deviation (SD); HR = heart rate; MAP =

mean arterial pressure; PCV = pressure-controlled mechanical ventilation; VCV = volume-controlled mechanical ventilation; BMI = body mass index; SpO2 = arterial oxygen saturation Table 2.

The primary efficacy endpoint was the percentage of patients with a

mean arterial pressure >= 75 mmHg or a 10 mmHg increase from baseline MAP at 3 hours following the initiation of study treatment without an increase in standard-of-care vasopressors.

Forty-eight hours into his admission, his lactate normalized but he was still requiring 0.9 mcg/kg/ min of norepinephrine and 0.04 unit/min of vasopressin to maintain a

mean arterial pressure greater than 60 mmHg.

We next examined the risk factors for development of PH using logistic regression analysis of systolic blood pressure, diastolic blood pressure,

mean arterial pressure, the proportion of arteriovenous fistula, serum BNP levels, phosphorus levels, CRP levels, albumin levels, hemoglobin levels, hypertensive nephropathy, right ventricular diameter, right ventricular outflow tract diameter, main pulmonary artery, left atrial diameter, interventricular septum thickness, ejection fraction, mitral regurgitation, and pericardial effusion.

BMI: Body mass index; DBP: Diastolic blood pressure; IOP: Intraocular pressure; MAP:

Mean arterial pressure; SBP: Systolic blood pressure; SD: Standard deviation

Mid-BP predicts overall cardiovascular disease better than systolic BP alone, diastolic BP alone, pulse pressure, or

mean arterial pressure, and its use permits researchers to study the effects of systolic and diastolic BP simultaneously.