mazindol


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mazindol

 [ma´zin-dol]
a sympathomimetic amine having amphetamine-like actions; used as an oral appetite suppressant.

mazindol

An amphetamine-like sympathomimetic used as a short-term supplement to diet and exercise in managing obesity; it inhibits cocaine binding to dopamine transporters in the brain, but is ineffective in attenuating cocaine craving.
 
Adverse effects
Restlessness, tremor, tachypnoea, confusion, panic, aggressiveness, nausea, vomiting, diarrhoea, arrhythmias, seizures.

mazindol

Teronac Pharmacology An agent that inhibits cocaine binding to dopamine transporters in the brain. See Cocaine.
References in periodicals archive ?
This sideways merger brings together the global operations and assets of the three companies in order to streamline the development of Nolazol, a controlled release formulation of mazindol that is currently being developed as a non-amphetamine DEA schedule C-4 treatment option for ADHD and narcolepsy, as well as a promising pipeline of early to late-stage compounds focusing on ADHD, sleep disorder and other rare diseases.
74) foram elaborados como parte de ensaio clinico configurado como: "Estudo simplescego, randomizado, controlado com placebo, para comparar durante 1 ano a eficacia e seguranca de sibutramina 15mg, dietilpropiona 75mg, femproporex 25mg, mazindol 2mg e fluoxetina 20mg em pacientes obesas".
Also in 2000, the European Medicines agency (EMA) recommended the market withdrawal of several anti-obesity drugs, including phentermine, diethylpropion, and mazindol, due to an unfavorable risk to benefit ratio.
Other highlight cases of litigation against regulations of Anvisa were the cases opposing Anvisa Directorate Resolutions 14/2012, which restricts the use of aromatic substances in cigarettes, and 52/2011, which prohibited the use of the substances fenproporex and mazindol, and set controls on prescription and dispensation of medications that contain sibutramine.
Although randomized controlled trials (RCTs) of at least 1 year were lacking, these sympathomimetic drugs showed a fair amount of efficacy, averaging approximately 3.0-3.6 kg weight loss relative to a placebo (26); of these drugs, mazindol was discontinued by the manufacturer in 1999.
Sendo assim, percebe-se que mesmo com a criacao da lei que delimita a comercializacao de anfetaminas, a RDC 50/2014, que dispoe sobre as medidas de controle de comercializacao, prescricao e dispensacao de medicamentos que contenham as substancias anfepramona, femproporex, mazindol e sibutramina, seus sais e isomeros, bem como seus intermediarios, o consumo de tais substancias ainda permanece elevado.
Data from NLS Pharma AG's mid-stage trial for its drug mazindol to treat attention deficit hyperactivity disorder (ADHD) showed it greatly reduced symptoms in adult patients, Reuters reported on Wednesday.
Nonspecific dopaminergic (DA) uptake determined in the presence of mazindol (10 mM) was subtracted from total uptake to obtain specific DA uptake.
El uso de psicoestimulantes (bupropion, dexanfetamina, metilfenidato, modafinil, mazindol, metanfetamina y selegiline) no ha demostrado efectos positivos en el tratamiento de dependencia a la cocaina (23).
(1978) llevaron a cabo un estudio en el cual compararon los efectos del mazindol, el dietilpropion y un placebo con una terapia conductual en la reduccion de peso en pacientes obesos.
(6,10-15) Strategies include adjunctive antipsychotic medications, mood stabilisers and novel anticonvulsants, antidepressants such as selective serotonin re-uptake inhibitors and others, glycinergic agents, dopamine agonists, mazindol, omega-3 fatty acids and electroconvulsive therapy (ECT).
The most commonly encountered interacting agents amongst them would be chlorpromazine, clomipramine, diltiazem, dopamine, fluphenazine, labetalol, mazindol, nifedipine, promethazine and salbutamol which may affect MIBG's diagnostic and therapeutic efficacy.