maximum tolerated dose


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dose

 [dōs]
the quantity to be administered at one time, as a specified amount of medication or a given quantity of radiation.
absorbed dose that amount of energy from ionizing radiations absorbed per unit mass of matter, expressed in rads.
air dose the intensity of an x-ray or gamma-ray beam in air, expressed in roentgens.
booster dose an amount of immunogen (vaccine, toxoid, or other antigen preparation), usually smaller than the original amount, injected at an appropriate interval after primary immunization to sustain the immune response to that immunogen.
curative dose (CD) a dose that is sufficient to restore normal health. See also median curative dose.
divided dose fractionated dose.
effective dose (ED) that quantity of a drug that will produce the effects for which it is administered. See also median effective dose.
erythema dose that amount of radiation that, when applied to the skin, causes erythema (temporary reddening).
fatal dose lethal dose.
fractionated dose a fraction of the total dose prescribed, as of chemotherapy or radiation therapy, to be given at intervals, usually during a 24-hour period.
infective dose (ID) that amount of a pathogenic agent that will cause infection in susceptible subjects. See also median infective dose and tissue culture infective dose.
lethal dose (LD) that quantity of an agent that will or may be sufficient to cause death. See also median lethal dose and minimum lethal dose.
loading dose a dose of medication, often larger than subsequent doses, administered for the purpose of establishing a therapeutic level of the medication.
maintenance dose the amount of a medication administered to maintain a desired level of the medication in the blood.
maximum tolerated dose tolerance dose.
maximum permissible dose the largest amount of ionizing radiation that one may safely receive within a specified period according to recommended limits in current radiation protection guides. The specific amounts vary with age and circumstance.
median curative dose (CD50) a dose that abolishes symptoms in 50 per cent of test subjects.
median effective dose (ED50) a dose that produces the desired effect in 50 per cent of a population.
median infective dose (ID50) that amount of pathogenic microorganisms that will produce demonstrable infection in 50 per cent of the test subjects.
median lethal dose (LD50) the quantity of an agent that will kill 50 per cent of the test subjects; in radiology, the amount of radiation that will kill, within a specified period, 50 per cent of individuals in a large group or population.
median tissue culture infective dose (TCID50) that amount of a pathogenic agent that will produce infection in 50 per cent of cell cultures inoculated.
minimum lethal dose
1. the amount of toxin that will just kill an experimental animal.
2. the smallest quantity of diphtheria toxin that will kill a guinea pig of 250-gm weight in 4 to 5 days when injected subcutaneously.
reference dose an estimate of the daily exposure to a substance for humans that is assumed to be without appreciable risk; it is calculated using the no observed adverse effect level and is more conservative than the older margin of safety.
skin dose (SD)
1. the air dose of radiation at the skin surface, comprising the primary radiation plus backscatter.
2. the absorbed dose in the skin.
threshold dose the minimum dose of ionizing radiation, a chemical, or a drug that will produce a detectable degree of any given effect.
threshold erythema dose (TED) the single skin dose that will produce, in 80 per cent of those tested, a faint but definite erythema within 30 days, and in the other 20 per cent, no visible reaction.
tissue culture infective dose (TCID) that amount of a pathogenic agent that will produce infection when inoculated on tissue cultures; used with a numeric qualifier.
tolerance dose the largest quantity of an agent that may be administered without harm. Called also maximum tolerated dose.

maximum tolerated dose

dose that produces grade 3 (severe) or grade 4 (life-threatening) toxicity in 30% or fewer of the patients tested.

maximum tolerated dose

The highest drug dose that can be given without causing unacceptable adverse side effects in most recipients.

maximum tolerated dose

Abbreviation: MTD
The most extensive exposure to a treatment that a patient may receive before he or she experiences unbearable side effects.
See also: dose
References in periodicals archive ?
In fact, the developmental neurotoxicity of parathion emerges only at doses exceeding the threshold for overt toxicity, whereas the corresponding effects of chlorpyrifos and diazinon are apparent at exposures below the maximum tolerated dose. Our findings thus emphasize the need to examine fetal and neonatal neurotoxicity of multiple organophosphates in a fashion similar to that already conducted for chlorpyrifos, as well as reinforcing the need for replacement of the "gold standard," cholinesterase inhibition, with biomarkers of neural development, the true end points for the developmental neurotoxicity of organophosphates.
The maximum tolerated dose or recommended Phase 2 dose in this trial was 24 mg/m2.
The maximum tolerated dose is expected to be able to deliver higher plasma levels than reported for the current commercially available inhaled treprostinil.
This first-in-human, open-label study's primary objective is to assess the safety and tolerability of increasing doses of GBR 1342 in multiple myeloma patients until a maximum tolerated dose is reached.
The study is expected to be conducted in two parts, with a dose escalation cohort to evaluate safety and tolerability and to determine the maximum tolerated dose of SEA-BCMA, followed by an expansion cohort to obtain further data regarding safety and antitumor activity.
This SAD/MAD study results indicate that PAT-1251 was generally well tolerated and a maximum tolerated dose (MTD) was achieved.
The primary objective of the study is to determine the maximum tolerated dose, or MTD, of TG-1701, with secondary objectives including evaluation of efficacy.
In the phase 1b dose-escalation segment of the trial, the primary objective is to determine the maximum tolerated dose (MTD) or recommended Phase 2 dose (RP2D), using a traditional 3+3 design.
The study will determine the maximum tolerated dose and recommended Phase II dose.
The primary endpoint of the Phase 1b study was to determine the maximum tolerated dose of Lenvima and Keytruda in combination.
Metastatic colorectal cancer patients who have received at least two prior lines of therapy will be enrolled in the dose-escalation part of the trial, and once a maximum tolerated dose is identified, additional patients whose tumours test high for the activated form of Notch1 will be enrolled in an expansion cohort.

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