maximum safe dose


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maximum safe dose

; MSD body mass-related maximum dose (of a pharmacological agent) that can be administered within a 24-hour period, usually quoted for a 70-kg adult; calculated as the product of body mass and the amount or percentage mass of drug used (Tables M3-M5); MSD cannot be increased in a patient weighing >70kg, and must be reduced proportionally for patients weighing <70kg, or with reduced liver/kidney function, or concurrently using e.g. beta-blockers, antiarrhythmic drugs or central nervous system-acting drugs (Table 1)
Table 1: Maximum safe doses of plain local anaesthetic agents (for 70Kg adult in 24 hours)
Agent (brand name)Maximum safe dose (70-kg adult)Dose per kg of body mass
Lidocaine (Xylocaine)200mg3mg/kg
Bupivacaine (Marcain)150mg2mg/kg
Levo-bupivacaine (Chirocaine)150mg2mg/kg
Mepivacaine (Scandonest)400mg6mg/kg
Prilocaine (Citanest)400mg6mg/kg
Ropivacaine (Naropin)250mg3.5mg/kg
References in periodicals archive ?
Because the trial is intended only to determine the maximum safe dose of that drug, researchers do not expect to see any improvement in the initial patients who will receive the lowest dose.
The study is designed to determine the maximum safe dose of ThermoDox([R]) when used in combination with microwave hyperthermia to treat RCW cancer, which is a recurrence of breast cancer at the chest wall of mastectomy patients.
While the Phase I study was designed to determine the maximum safe dose and safety profile of ThermoDox, additional analyses will be undertaken to evaluate any clinical effects achieved during the study.

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