GCK

(redirected from maturity-onset diabetes of the young 2)

GCK

A gene on chromosome 7p15.3-p15.1 that encodes a glucokinase (hexokinase) that phosphorylates glucose yielding glucose-6-phosphate, the first usual step in glucose metabolism.

Molecular biology
GCK mutations are linked to type-2 diabetes, maturity-onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycaemia of infancy (PHHI).
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References in periodicals archive ?
Li et al., "Long-term renal changes in the liver-specific glucokinase knockout mouse: implications for renal disease in maturity-onset diabetes of the young 2," Translational Research, vol.
An altered ability to sense the environment can produce hormone deficiency (e.g., glucokinase mutations producing maturity-onset diabetes of the young 2).

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