maturity-onset diabetes


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maturity-onset diabetes

Type 2 di·a·be·tes

(tīp dī-ă-bē'tēz)
A condition characterized by high blood glucose levels caused by either a lack of insulin or the body's inability to use insulin efficiently. Type 2 diabetes develops most often in middle-aged and older adults but can appear in young people.
Synonym(s): maturity-onset diabetes, non-insulin-dependent diabetes mellitus.

maturity-onset diabetes

DIABETES MELLITUS developing in or after middle age and caused by a relative insufficiency of INSULIN production by the PANCREAS. The condition is of more gradual development than insulin-dependency diabetes and can often be treated by diet or oral HYPOGLYCAEMIC drugs rather than by insulin. In general, it is associated with less severe symptoms than juvenile-onset (Type I) diabetes, but complications such as eye and kidney disease are common. Also known as Type II diabetes.
References in periodicals archive ?
Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes.
Maturity-onset diabetes of the young (MODY) at least 10 times more common in Europe than previously assumed.
Maturity-Onset Diabetes of the Young (MODY) is a clinically heterogeneous group of disorders characterized by nonketotic diabetes, an autosomal dominant pattern of inheritance, and typical onset below the age of 25 years.
They also identified genes responsible for myotonic dystrophy (141: 102), maturity-onset diabetes of the young (141: 300), two forms of the eye disorder macular degeneration (142: 37), and a gene that predisposes women to breast cancer following exposure to extremely low doses of radiation (141: 4).
This has been most clearly demonstrated for several of the genes responsible for the syndrome designated maturity-onset diabetes of the young (MODY) [2] (13).
CHICAGO -- Approximately 5% of antibody-negative /C-peptide-positive children and adolescents who are diagnosed with diabetes in the United States may have maturity-onset diabetes of the young rather than type 2 diabetes, Dr.
Other research by his team suggests that identification of two phenotypes of maturity-onset diabetes of the young (MODY) can allow beneficial changes in treatment--even in patients who have had up to 30 years of suboptimal therapy.
Between 100,000 and 500,000 people in the United States suffer from maturity-onset diabetes of the young (MODY), an uncommon form of Type II diabetes that develops before age 25.
Mutations in the glucokinase gene lead to an impaired sensing of blood glucose by the pancreatic [beta] cell, causing an autosomal dominant form of type 2 diabetes, maturity-onset diabetes of the young type 2 (MODY2).
Mutations in the hepatocyte nuclear factor-4 alpha gene in maturity-onset diabetes of the young (MODY1).

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