Promyelocyte, myelocyte, metamyelocyte, band and mature neutrophil
forms were absent.
G-CSF is a glycoprotein that influences the survival, proliferation, differentiation, and function of mature neutrophil
granulocytes and their precursors .
The researchers counted 200 mature neutrophils
and expressed them as a percentage of toxic granulated neutrophils in mature neutrophil
Laboratory blood tests at hospital admission showed a leukocyte count of 13,400 cells/[mm.sub.3] (with a mature neutrophil
count of 87%), hemoglobin of 10.8 g/dL, and a platelet count of 611,000 cells/[mm.sub.3]; electrolyte levels and results of liver function tests were normal, but a total cholesterol count of 267 mg/dL and a triglyceride level of 440 mg/dL were found.
Neutrophils derived from bone marrow hematopoietic stem cells, which undergoes multiple developmental stages, such as myeloblast, premyelocyte, myelocyte, metagranulocyte, band neutrophils, and eventually develop into mature neutrophils
. Neutrophils are the main component of leukocytes in the human circulation, which percentage accounting for 60%~70%, and are the first non-specific immunocytes to arrive at the site of infection through the pathway of transendothelial migration.
Eight of 11 cases (72%) in the study group showed detached intracytoplasmic inclusions in mature neutrophils
consistent with Howell-Jolly body-like inclusions (Figure, a through d).
Wide expression of pyrin in mature neutrophils
suggests that this protein may provide down regulation of the inflammation mediators (26,27).
IL-3, which activates mature neutrophils
and macrophages, was also significantly decreased.
Bone marrow analysis revealed a maturation arrest at the promyelocyte/myelocyte stage with few mature neutrophils
; there was no evidence of malignant involvement in the bone marrow.
Classical Sweet's syndrome is characterized by the physical findings described above with a diffuse infiltrate consisting predominantly of mature neutrophils
located in the upper dermis on pathology.
Her total count was 22000 per cu.mm, predominant were mature neutrophils
and stab forms (Figure 4).
Soon, however, our body runs out of mature neutrophils
and begins pushing immature ones into our system.