A back-up maturation inhibitor
candidate (BMS-986173) is also included in the purchase.
The Bristol-Myers Squibb clinical stage HIV pipeline reportedly includes an attachment inhibitor (BMS-663068) that is being investigated in Phase III as a therapeutic option for heavily treatment-experienced patients as well as a maturation inhibitor
(BMS-955176) that is being investigated in Phase IIb development for treatment-naive and treatment-experienced patients.
Other maturation-preventing factors in follicular fluid are oocyte maturation inhibitor
(57) and hypoxanthine, (58) which acts only in combination with cAMP.
In vitro resistance to HIV-1 maturation inhibitor
Food and Drug Administration for the company's second-generation HIV maturation inhibitor
released results of a small, 10-day human trial of the maturation inhibitor
PA-457, the first time more than a single dose of this compound has been tested in HIV-positive people.
PA-457: A possible new kind of drug called a "maturation inhibitor
" interrupts the HIV life cycle at a late step, causing "immature" (non-infectious) viruses to be produced.
Bevirimat (Panacos Pharmaceuticals) is an HIV maturation inhibitor
. A Phase IIb study (Study 203) was performed on five treatment-experienced patient cohorts with doses ranging up to 400 mg/day.
In 2014, He received the prestigious James Palmer Award for excellence in drug development (BMS R&D award), especially for his leadership in accelerating the pace of innovation, and his team's accelerated development of HIV-1 Maturation Inhibitors
There are also other drugs in the integrase and CCR5 inhibitor classes that are in development, and additional promising new classes, such as maturation inhibitors
, are being actively evaluated in clinical trials.