maturation arrest


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arrest

 [ah-rest´]
sudden cessation or stoppage.
cardiac arrest see cardiac arrest.
epiphyseal arrest premature arrest of the longitudinal growth of bone due to fusion of the epiphysis and diaphysis.
maturation arrest interruption of the process of development, as of blood cells, before the final stage is reached.

mat·u·ra·tion ar·rest

cessation of complete differentiation of cells at an immature stage; in spermatogenic maturation arrest, the seminiferous tubules contain spermatocytes, but no sperms develop.

maturation arrest

Haematology
The presence of relatively mature cytoplasm and an immature nucleus, seen in patients with megaloblastic anaemia due to a deficiency of vitamin B12 and/or folic acid, and in acute leukaemias.

Maturation arrest affects all cells, is most prominent in the bone marrow, and is characterised by enlarged cells with delicate, open chromatin and prominent parachromatin. This nuclear:cytoplasmic asynchrony is due to decreased DNA synthesis and a block in mitosis, attributed to the slowing of cobalamin-dependent pathway of methionine synthesis; this in turn sequesters folate as N5-methyl FH4, which cannot be used by thymidylate synthetase to generate dTMP from dUMP.

mat·u·ra·tion ar·rest

(mach'ūr-ā'shŭn ă-rest')
Cessation of complete differentiation of cells at an immature stage; in spermatogenic maturation arrest, the seminiferous tubules contain spermatocytes, but no sperms develop.
References in periodicals archive ?
However, in our study patients with AZFc deletion showed SCO syndrome or maturation arrest in histological analysis.
(mIU/ml) (mIU/ml) biopsy A1 60 12 NA NA NA A8 45 10 SCO NA NA Inf4 76 12 MA TESE - Inf6 70 10.5 MA TESE - Inf13 60 17 MA TESE - Inf24 30 19 MA TESE - Inf38 25 12 MA TESE - Inf52 20 18 MA TESE - Inf104 40 20 SCO TESE - Inf121 10 7.5 SCO TESE - Y2 38.5 7 NA TESE - Y30 35 14 NA TESE - FSH, follicule-stimulating hormone; LH, leuterizing hormone; NA, not available; SCO, sertoli cell only; MA, maturation arrest; TESE, testicular sperm extraction; -, no sperm.
There should be homogenous spermatocyte maturation arrest in all the tubules obtained in the biopsy.
Testicular phenotype in these subjects ranged from maturation arrest to SCO I and SCO II syndrome (Table I).
Three cases had normal spermatogenesis, two cases had hypospermatogenesis, two cases had maturation arrest, two cases had testicular atrophy and sertoli cell syndrome on histopathology, in one case the biopsy was inadequate.
Multiple histologic patterns were noted in the seminiferous tubules that contained inflammatory infiltrates or in the tubules adjacent to the interstitial inflammatory infiltrates: hypospermatogenesis (1 testis) (Figure 4); spermatogonial maturation arrest (2 testes) (Figure 1); tubules with intratubular germ cell neoplasia (1 testis) (Figure 5); Sertoli cell-only tubules (16 testes) (Figures 2 and 6); hyalinized tubules (10 testes, 9 of which also showed inflammatory infiltrates in other tubule types [Sertoli cell-only tubules in 7 testes, tubules with intratubular germ cell neoplasia in 1 testis, and tubules with hypospermatogenesis in 1 testis]) (Table 2).
In testes normal seminiferous tubules with maturation arrest and normal glandular elements was found.
In 1926, Pick proposed that the trophoblastic elements in a visceral carcinoma develop by the process of opisthoplasia or retrodifferentiation of the carcinoma cell.[11] Rather than retrodifferentiation or dedifferentiation, the process might be better described as blocked differentiation or a maturation arrest in stem cells that is controlled by regulation of the genome.[12] Since all somatic cells contain 46 chromosomes, in theory, each cell has totipotentiality.
A differential count was performed for each bone marrow specimen to determine the degree of maturation arrest, as assessed morphologically, in patients with MDS compared with controls.