matrix-assisted laser desorption ionisation

matrix-assisted laser desorption ionisation

A process in mass spectrometry in which sample molecules are mixed with an excess of an energy-absorbing matrix and co-crystallised in a thin film on an inert metal support. Repeated irradiation of the film with a pulsed laser releases ions from the surface, which can be accelerated into a time-of-flight mass spectrometer. Because the matrix is usually a solid organic acid, the predominant mode of ionisation is protonation of the sample molecule M to form M H.
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Contract award notice: The supply, Delivery, Installation and maintenance of a matrix-assisted laser desorption ionisation mass spectrometry system for imaging of drugs and biomolecules in tissue (united kingdom-cheshire: Laboratory, Optical and precision equipments (excl.
Further analysis using matrix-assisted laser desorption ionisation time of flight mass spectrometry (MALDI-TOF MS) identified the causative organism as A.
Matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF MS) has recently been introduced into clinical microbiology laboratories in New Zealand and overseas.
Matrix-assisted laser desorption ionisation time-of-flight mass spectrometry for identification of clinically significant bacteria that are difficult to identify in clinical laboratories J.
The recommended tests include Dutch Qiagen's (ETR:QIA) Therascreen KRAS RGQ PCR Kit, German TIB MolBiol's KRAS LightMix Kit, as well as the methods pyrosequencing of codons 12, 13 and 61, and MALDI-TOF (matrix-assisted laser desorption ionisation time-of-flight) mass spectrometry of codons 12, 13 and 61.
The assays are utilised to determine hemoglobin variants and diabetes risk, using Bruker's Matrix-Assisted Laser Desorption Ionisation (MALDI) Biotyper platform for clinical mass spectrometry and based on intellectual property developed at the UVic GBC Proteomics Centre.
The new Matrix-Assisted Laser Desorption Ionisation time-of-flight mass spectrometry based test for hbA1c and genetic hemoglobin variants is intended for use on the MALDI Biotyper platform is likely to provide specificity, accuracy, speed of analysis and cost per analysis.
It covers techniques such as electron and chemical jonisation and newer soft ion-isation techniques such as matrix-assisted laser desorption ionisation and electrospray.
Contract notice: The supply, Delivery, Installation and maintenance of a matrix-assisted laser desorption ionisation mass spectrometry system for imaging of drugs and biomolecules in tissue
Contract: the supply, delivery, installation and maintenance of a matrix-assisted laser desorption ionisation - mass spectrometry system for imaging of drugs and biomolecules in tissue