MMP9

(redirected from matrix metalloproteinase-9)

MMP9

A gene on chromosome 20q12-q13 that encodes matrix metalloproteinase 9, which degrades collagens IV and V, gelatins I and V, and fibronectin. It is thought to play a key role in local proteolysis of the extracellular matrix and in leukocyte migration, and may play a role in osteoclastic resorption of bone.

Molecular pathology
Defects in MMP9 increase susceptibility to intervertebral disc disease and lumbar disc herniation; MMP9 defects cause metaphyseal anadysplasia type 2.
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References in periodicals archive ?
Matrix metalloproteinase-9 deficiency attenuates diabetic nephropathy by modulation of podocyte functions and dedifferentiation.
[7.] Ganguly K, Maity P (2005) Effect of melatonin on secreted and induced matrix metalloproteinase-9 and -2 activity during prevention of indomethacin-induced gastric ulcer.
Shooter, "Increased matrix metalloproteinase-9 (MMP-9) activity observed in chronic wound fluid is related to the clinical severity of the ulcer," British Journal of Dermatology, vol.
Matrix metalloproteinase-9 (MMP-9), a zinc-dependent proteinase, is released by various inflammatory cells, predominantly neutrophils and macrophages.
Kita, "A bout of treadmill exercise increases matrix metalloproteinase-9 activity in the rat hippocampus," Neuroscience Letters, vol.
Yong, "Combination of thrombin and matrix metalloproteinase-9 exacerbates neurotoxicity in cell culture and intracerebral hemorrhage in mice," The Journal of Neuroscience, vol.
Among these biomarkers are aldehyde-detoxification and oxidative-stress-related proteins, thioredoxin (TXN), and matrix metalloproteinase-9 (MMP9).
With these extracted monomers, we further explored the effect of Dahuang monomerson increased permeability of monolayer endothelial cells induced by matrix metalloproteinase-9.[sup][4] It was found that five Dahuang monomers had protective effects on VECs injured by inflammatory factors by reducing the permeability of monolayer VECs and preventing capillary leakage.
Targeting filamin B induces tumor growth and metastasis via enhanced activity of matrix metalloproteinase-9 and secretion of VEGF-A.

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