MMP20

(redirected from matrix metalloproteinase-20)

MMP20

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 20, which degrades amelogenin, the major protein of the enamel matrix, and two macromolecules of the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein. MMP20 may play a central role in tooth enamel formation. It is also the retired HUGO symbol for what is now designated MMP25, see there.

Molecular pathology
Defects in MMP20 cause amelogenesis imperfecta type 2A2.
References in periodicals archive ?
During enamel secretion and maturation (Haruyama et al., 2010), these secreted amelogenins are degraded by proteinases such as matrix metalloproteinase-20 (MMP-20) and kallikrein 4 (KLK4) into various smaller amelogenin peptides, including tyrosinerich amelogenin peptide (TRAP), and amelogenin as well as other organic matrices in the enamel, are almost totally removed during the mineralization of enamel before tooth eruption.
The localization of matrix metalloproteinase-20 (mmp-20) in mature human teeth.

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