MMP15

(redirected from matrix metalloproteinase-15)

MMP15

A gene on chromosome 16q13 that encodes matrix metalloproteinase 15, an endopeptidase that degrades components of the extracellular matrix and may activate progelatinase A. Unlike other matrix metalloproteinases, which are secreted as inactive proproteins and activated when cleaved by extracellular proteinases, MMP15 is a transmembrane protein that is activated from its precursor by furin endopeptidase cleavage.
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References in periodicals archive ?
Multiple steps of HLA-G in ovarian carcinoma metastasis: alter NK cytotoxicity and induce matrix metalloproteinase-15 (MMP-15) expression.
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