MMP14

(redirected from matrix metalloproteinase-14)

MMP14

A gene on chromosome 14q11-q12 that encodes matrix metalloproteinase 14, which specifically activates progelatinase A. It may be involved in actin cytoskeleton reorganisation by cleaving PTK7. Unlike other matrix metalloproteinases, which are secreted as inactive proproteins and activated when cleaved by extracellular proteinases, MMP14 is a transmembrane protein that is activated from its precursor by furin endopeptidase cleavage.

Molecular pathology
MMP14 may trigger invasion by tumour cells by activating progelatinase A on the surface of tumour cells.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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References in periodicals archive ?
Naa et al., "Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis," Cancer Research, vol.
Seven matrix metalloproteinases have been shown to be expressed under varying circumstances in articular cartilage--matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-3 (MMP-3), matrix metalloproteinase-8 (MMP-8), matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase-13 (MMP-13), and matrix metalloproteinase-14 (MMP-14).
Wiercinska et al., "Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis," Cancer Research, vol.
Fee, "Cleavage and functional loss of human apolipoprotein E by digestion of matrix metalloproteinase-14," Proteomics, vol.

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