matrix metalloproteinase-11

matrix metalloproteinase-11

A matrix metalloproteinase encoded on chromosome 22q11.2 which degrades extracellular matrix, collagens and other tissue substrates.

Cytokine inducers
EGF, FGF-b, IGF-II, IL-6, PDGF, TGF-alpha.
 
Substrates
Alpha1-antitrypsin, alpha2-macroglobulin, casein, IGF-binding protein-1.

Normal expression
Increased expression and activation during wound healing; migration and extracellular matrix remodeling is accompanied by acquisition of a mesenchymal phenotype in respiratory epithelial cells.

Abnormal expression
MMP-11 appears in the desmoplastic stroma of invasive, but not in situ, breast carcinoma; its transcription may be induced by diffusible cytokines (e.g., PDGF, fibroblast growth factor, TGF-alpha), providing a mechanism by which malignant cells destroy basement membranes and invade tissues.
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References in periodicals archive ?
Matrix metalloproteinase-11 as a marker of metastasis and predictor of poor survival in urothelial carcinomas.
(2012) The Role of Matrix Metalloproteinase-11 (MMP11) in Human Uterine Leiomyomas.

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