matrix metalloproteinase inhibitor


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matrix metalloproteinase inhibitor

An inhibitor of matrix metalloproteinases, which may be native (tissue inhibitors of metalloproteinase, or TIMPs) or synthetic. They are of interest to the pharmaceutical industry as potential therapeutic agents, as MMPs have been implicated in a vast array of human disorders, including arthritis, cancer and connective tissue diseases.

matrix metalloproteinase inhibitor

An agent that inhibits cancer cells by blocking their abilities to invade tissues, demand new blood supply, and metastasize.
See also: inhibitor
References in periodicals archive ?
[15] E.Breuer, J.Frant, and R.Reich, "Recentnon-hydroxamate matrix metalloproteinase inhibitors," Expert Opinion on Therapeutic Patents, vol.
Mobashery, "Effect of synthetic matrix metalloproteinase inhibitors on lipopolysaccharide-induced blood-brain barrier opening in rodents: differences in response based on strains and solvents," Brain Research, vol.
Opdenakker, "Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases," Nature Reviews Drug Discovery, vol.
Matrix metalloproteinase knockout studies and the potential use of matrix metalloproteinase inhibitors in the rheumatic diseases.

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