matrix metalloproteinase 8

matrix metalloproteinase 8

An enzyme encoded on chromosome 11q21-q22 which degrades collagens and other tissue substrates.

Cytokine inducers 
IL-1β, TNF-α.
 
Substrates
Collagens I, II, III, V, VII, VIII and X; gelatin; aggrecan; α1-AT; α1-ACHYM; α2-antiplasmin; fibronectin.
References in periodicals archive ?
Pacora et al., "Human neutrophil collagenase (matrix metalloproteinase 8) in parturition, premature rupture of the membranes, and intrauterine infection," American Journal of Obstetrics and Gynecology, vol.
Overall, "Matrix metalloproteinase 8 deficiency in mice exacerbates inflammatory arthritis through delayed neutrophil apoptosis and reduced caspase 11 expression," Arthritis and Rheumatism, vol.

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