matrix metalloproteinase 13

matrix metalloproteinase 13

An enzyme encoded on chromosome 11q22.3 which degrades extracellular matrix and other tissue substrates.

Cytokine inducers
EGF, FGF-b, FGF-7, IGF-1, IL-1β, IL-6, IL-13, LIF, oncostatin M, PDGF, PDGF-BB, TGF-α, TGF-β1, TGF-β2, TNF-α.
 
Substrates
Collagens I, II and III, IV, IX, X and XIV; gelatin, α1-ACHYM and plasminogen activator inhibitor 2; aggrecan; perlecan; large tenascin-C and fibronectin; osteonectin; MMP-9.
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References in periodicals archive ?
We evaluated the expression of some key genes (nuclear factor kappa B (NF[kappa]B), matrix metalloproteinase 13 (MMP-13), a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4), collagen type I alpha 1 (cOl1A1), collagen type II alpha 1 (COL2A1), and cartilage oligomeric matrix protein (COMP)) implicated in joint homeostasis and pathology.
We also assessed RNA from IGF-1-transduced cells and control cells for mRNA transcript levels for the chondrogenic marker gene type II collagen alpha1 (Col2A1), as well as the hypertrophic marker type X collagen (Col10), matrix metalloproteinase 13 (MMP-13), and the osteogenic marker genes ALP and Osterix.
Partridge, "Sirtuin 1 is a negative regulator of parathyroid hormone stimulation of matrix metalloproteinase 13 expression in osteoblastic cells: role of sirtuin 1 in the action of PTH on osteoblasts," The Journal of Biological Chemistry, vol.
Loeser, "Stress-inducible nuclear protein 1 regulates matrix metalloproteinase 13 expression in human articular chondrocytes," Arthritis & Rheumatology, vol.
Bendele et al., "A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models," Arthritis and Rheumatism, vol.
Interleukin-1 induction of col-lagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collage-nase 1 and collagenase 3.

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