matrix metalloproteinase 12

matrix metalloproteinase 12

An enzyme encoded on chromosome 11q22.3 which degrades extracellular matrix and other tissue substrates.

Cytokine inducers
CD40L, GM-CSF, IL-1β, IL-13, MCP-1, M-CSF, PDGF-BB, TNF-α, VEGF.
 
Substrates
Collagen IV; gelatin; elastin and k-elastin; casein; α1-AT; fibronectin; vitronectin; laminin; entactin; proteoglycan monomer; GST-TNF; MBP; fibrinogen; fibrin; plasminogen.
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References in periodicals archive ?
The MMP12 gene encodes matrix metalloproteinase 12, which is produced by macrophages, "the predominant cell type that patrols the lower airspaces under normal conditions and the main inflammatory cell type that is recruited with smoking," the investigators noted.
They found a link between a SNP in MMP12, a gene that encodes matrix metalloproteinase 12, and better preserved lung function among both children with asthma and adults who are former or current smokers.

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