MMP9

(redirected from matrix metallopeptidase 9)

MMP9

A gene on chromosome 20q12-q13 that encodes matrix metalloproteinase 9, which degrades collagens IV and V, gelatins I and V, and fibronectin. It is thought to play a key role in local proteolysis of the extracellular matrix and in leukocyte migration, and may play a role in osteoclastic resorption of bone.

Molecular pathology
Defects in MMP9 increase susceptibility to intervertebral disc disease and lumbar disc herniation; MMP9 defects cause metaphyseal anadysplasia type 2.
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References in periodicals archive ?
Previous study suggested that many genes and signalling pathway are involved in early pregnancy, and some genes are essential for maintaining pregnancy, and the miscarriage was triggered by the dysfunction of these genes, such as cadherin 2 (CDH2), which is a gene of cell adhesion molecules (CAMs) [5]; collagen type VI alpha 3 chain (COL6A3), thrombospondin 1 (THBS1), fibronectin 1, integrin beta 4 (ITGB4) [6], which are all PI3KAkt signaling pathway genes; matrix metallopeptidase 14 (MMP14), vascular cell adhesion molecule 1 (VCAM1) [7], matrix metallopeptidase 9 (MMP9), which are all tumor necrosis factor (TNF) signaling pathway genes; additionally, MAPK signaling pathway [8] and Hippo signaling pathway [9] are involved in maintaining pregnancy.
hSDS: height standard deviation score; MMP-1: matrix metalloproteinase-1; MMP-2: matrix metalloproteinase-2; TIMP-1: tissue inhibitor of metalloproteinase-1; MMP-9: matrix metallopeptidase 9; BDNF: brain-derived neurotrophic factor; VEGF: vascular endothelial growth factor; fT4: unbound [T.sub.4]; TSH: thyroid-stimulating hormone; ALT: alanine transaminase; AST: aspartate transaminase; IGF-1: insulin-like growth factor 1.

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