matrix effect

(1) The difference between the value of an analyte from a fresh patient specimen and from stabilised processed reference materials.
(2) The influence of a sample property—other than the level of the substance or property being measured in the analyte—on a measurement, and thus on the value of the measurand. Matrix effects include physicochemical, mechanistic and analytical interferences, and the presence of isoforms of the substance being measured.

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Breath pad recovery, overall extraction efficiency, and matrix effect for cannabinoids in breath collected with the SensAbues device.

Cannabinoids in exhaled breath following controlled administration of smoked cannabis

In order to reduce matrix effect in LC/MS/MS, the following step is necessary:

Analytical Challenges Forensic Screening of drugs of abuse

Calibration Curves for Quantitative Analysis and Matrix Effect. Two calibration curves were built in HPLC-MS/MS, in MRM mode.

Hydrophilic Interaction Liquid Chromatography-Tandem Mass Spectrometry Analysis of Fosetyl-Aluminum in Airborne Particulate Matter

Q Do all control materials have a matrix effect, even if derived from fresh-frozen human plasma?

Matrix effect for controls?

A validation of this method was in accordance with the FDA guidelines, including selectivity, linearity, precision, accuracy, recovery, matrix effect, and stability [25].

Pharmacokinetics and Bioavailability Study of Tubeimoside I in ICR Mice by UPLC-MS/MS

A value of 100% indicates that the response in the neat samples and the matrix extracts were the same and no absolute sample matrix effect was observed.

Isotope-dilution liquid chromatography-tandem mass spectrometry candidate reference method for total testosterone in human serum

The items of validation included selectivity, matrix effect, linearity, precision, accuracy, recovery rate, and stability.

Pharmacokinetics and UPLC-MS/MS of Delsoline in Mouse Whole Blood

Simulating the aesthetics, viscosity, flow dynamics, and wetting properties of fresh whole blood, Sugar-Chex Linearity performs like whole blood, eliminating the matrix effect often seen in aqueous products.

Linearity product like whole blood. (Product Watch)

The experiments to evaluate matrix effect and recovery were conducted by the protocol [26].

Metabolite Profiling, Pharmacokinetics, and In Vitro Glucuronidation of Icaritin in Rats by Ultra-Performance Liquid Chromatography Coupled with Mass Spectrometry

Extraction Recovery and Matrix Effect. The matrix effect was assessed by using the postextraction spike method as indicated by RSC guideline for LC-MS measurements [30].

Development of a LC-MS/MS Method for the Simultaneous Detection of Tricarboxylic Acid Cycle Intermediates in a Range of Biological Matrices

The terms "matrix-related bias" and "matrix effect" are used to refer to the component of bias that is caused by noncommutability.

Proficiency testing/external quality assessment: current challenges and future directions

The method was validated in terms of linearity, sensitivity, precision, accuracy, recovery, matrix effect, and stability and successfully applied to pharmacokinetic and tissue distribution studies in female healthy Sprague-Dawley rats following a single oral administration of Herba Epimedii extract (containing 15 mg/g epimedin B).

Determination of Epimedin B in Rat Plasma and Tissue by LC-MS/MS: Application in Pharmacokinetic and Tissue Distribution Studies