matrix Gla protein
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Related to matrix Gla protein: Osteocalcin, protein S
ma·trix Gla pro·tein (MGP),
a calcium binding protein.
Also found in: Dictionary, Thesaurus, Financial, Acronyms, Encyclopedia.
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References in periodicals archive
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Matrix GLA protein, a regulatory protein for bone morphogenetic protein-2.
dp-ucMGP: dephosphorylated-uncarboxylated matrix Gla protein: BMD: bone mineral density.
Increased levels of the calcification marker matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart disease.
Price, "Lung, heart, and kidney express high levels of mRNA for the vitamin K-dependent matrix Gla protein. Implications for the possible functions of matrix Gla protein and for the tissue distribution of the [gamma]-carboxylase," The Journal of Biological Chemistry, vol.
Matrix GLA Protein - Vitamin K2 = Vascular/soft tissue calcification
For example, the Gla-protein in bone, called osteocalcin, is responsible for making sure calcium is deposited in bones, while the Gla-protein in arterial walls, called matrix Gla protein, prevents calcium from being deposited in arteries.
If enough K2 is present, these proteins prevent calcium infiltration into soft tissues.33-37 (The name of this vitamin K-dependent calcium-blocking protein in arteries is matrix Gla protein).
Matrix GLA protein and BMP-2 regulate osteoinduction in calcifying vascular cells.
Vitamin K is critical to ensure optimal carboxylation of matrix Gla protein (MGP) in healthy subjects.
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