MMP26

(redirected from matrilysin 2)

MMP26

A gene on chromosome 11p15 that encodes membrane-type matrix metalloproteinase 26, which activates progelatinase B and may hydrolyse collagen type IV, fibronectin, fibrinogen, beta-casein, type-I gelatin and alpha-1 proteinase inhibitor. MMP26 is expressed specifically in the uterus and placenta, and widely expressed in various malignancies.
References in periodicals archive ?
2-4) Secreted-type MMPs can be classified into 6 subgroups according to their substrate specificity and structural differences (2): (1) collagenases, including tissue collagenase (MMP1), neutrophil collagenase (MMP8), and collagenase 3 (MMP13); (2) gelatinases, such as gelatinase A (MMP2) and gelatinase B (MMP9); (3) stromelysins, including stromelysin 1 (MMP3) and stromelysin 2 (MMP-10); (4) matrilysins, such as matrilysin 1 (MMP7) and matrilysin 2 (MMP26); (5) furin-activated MMPs, including stromelysin 3 (MMP-13) and epilysin (MMP 28); and (6) other MMPs such as metalloelastase (MMP12), MMP19, enamelysin (MMP-20), MMP21, and MMP-27.