One of the causative mechanisms for preeclampsia is thought to be impaired trophoblastic remodeling that impedes development of the low-resistance vascular system of the maternal-fetal unit
. "The resulting pathophysiology is multisystemic and includes vascular and endothelial dysfunction, placental ischemia, and an inflammatory and stress response," Dr.
The disparate nature of CPF effects on brain development, combined with potential impact on the maternal-fetal unit
or general aspects of fetal or neonatal growth and development, renders it especially difficult to identify specific underlying mechanisms from in vivo studies or to discern why specific developmental stages or neurotransmitter systems might be especially targeted by CPF.
"Every cardiovascular document before this has begun at age 2 years, but in this one we go all the way back to the maternal-fetal unit
since there's emerging research that the prenatal environment has an influence on the development of risk factors," he said.