Some lesions, such as chronic intervillositis, high-grade villitis of unknown etiology, and maternal floor infarction
, are important by virtue of their high recurrence risk and their association with adverse pregnancy outcomes.
Maternal floor infarction
and massive perivillous fibrin deposition: histological definitions, association with intrauterine foetal growth restriction, and risk of recurrence.
(7) Other placental lesions which have been seen in thrombophilic females are massive perivillous fibrin deposition (maternal floor infarction
), subchorionic haemorrhage and uteroplacental vasculitis.
Chronic histiocytic intervillositis has been suggested to be along the spectrum of the more recognized lesion known as villitis of unknown etiology, (5) along with massive perivillous fibrin deposition and maternal floor infarction
. (6) Increased perivillous fibrin is often seen in association with CHI.
The underdiagnoses included, in decreasing frequency, HEV (84.6%), fetal thrombotic vasculopathy (75%), MPFD (68.4%), maternal floor infarction
(66.7%), retroplacental hemorrhage (60.6%), intervillous thrombus (57.1%), decidual angiopathy (33.3%), infarction (25.4%), acute chorioamnionitis (22.7%), and VUE (21.7%).