Abbreviations HSCT - hematopoietic stem cell transplantation MUD - matched unrelated donors
GvHD - Graft versus host disease Bu/Cy - Busulfan/Cycloposphamide Flu/Mel - Fludarabine/Melphalan Bu/Flu+ATG - Busulfan/Fludarabine+ Antithymocyte globuline CMV - cytomegalovirus RIC - reduced intensity conditioning ANC - absolute neutrophil count TRM - transplant related mortality Since 2013, MUD HSCT has been performed routinely in the Military Medical Academy.
He had gone through relapses and multiple chemotherapy regimens and was planned for a matched unrelated donor
Bellicum Pharmaceuticals announced late interim results from its BP-004 European registration trial, suggesting that adding rivo-cel to stem cell transplants in patients who lack a matched donor may deliver comparable outcomes to matched unrelated donor
Moderate to severe GvHD (with grade II being moderate and grade III-IV GvHD being severe) occurs in 30-50 percent of matched related hematopoietic stem cell transplants (HSCT) and 50-70 percent of matched unrelated donor
recipients, as shown in the literature describing historical clinical experience.