According to Mathews and Murphy (1982) , DEC inhibits the formation of LTB4 and sulfidopeptide leukotrienes, which are potent vaso/bronchoconstrictors, in mastocytomas
, while stimulating the formation of 5-hydroxyeicosatetraenoic acid, suggesting that the site of action of DEC for inhibiting leukotrienes formation may be the leukotriene [A.sub.4] synthetase reaction.
Kinavet contains mastinib, an anti-cancer drug designed for use with dogs suffering from aggressive mast cell tumors (mastocytoma
The Swedish company will use the proceeds to invest in production capacity, inventory build-up prior to the launch of Paccal Vet for the treatment of mastocytoma
(skin cancer) in dogs and to complete the Phase III study of Paclical for the treatment of ovarian cancer in humans.
cDNA-derived amino acid sequence of L-histidine decarboxylase from mouse mastocytoma
P815 is a cell line derived from a mastocytoma
in DBA/2 (H-[2.sup.d]) mice, and it expresses class I H-[2.sup.d] molecules (Plaut et al.
So, the other round cell tumors, such as histiocytoma, mastocytoma
, lymphoma, plasmacytoma, melanoma were excluded.
(1) The category of cutaneous mastocytosis also includes diffuse cutaneous mastocytosis (characterized by generalized erythema and thickened skin), solitary mastocytoma
(present as a solitary brown or red lesion), and telangiectasia macularis eruptiva perstans (diffuse telangiectatic macules on the skin, usually in adult patients).
Results: All patients had cutaneous mastocytosis, 19 patients had urticaria pigmentosa and 2 patients had mastocytoma
. The male-female ratio was: 1/1.6.
Recently, there is also a report that Schisandra lignans can prevent hepatic metastasis of mouse mastocytoma
P815 tumor cells (Tang et al.
Other CD117 positive tumors include clear cell sarcoma, gastrointestinal stromal tumors, (16) mastocytoma
, and myeloid leukemia.
Other forms are solitary mastocytoma
, and less commonly, diffuse cutaneous mastocytosis.
Based on history and clinical examination, the case was suspected for cutaneous solitary mastocytoma