The IgE levels of patients with allergic diseases during an attack being statistically higher than the IgE levels during the interictal period is supported by the suggestion that IgE is a mediator of histamine release from mastocytes
and, histamine, as a potent vasoactive agent, may play a role in the induction of migraine attacks.
The complex formed is recognized by mastocytes
, eosinophils and neutrophils, which release the content of their granules (histamine, leukotrienes, prostaglandins and other mediators).
and microglia are efficient sensors of adverse endogenous or exogenous conditions of the CNS [2, 6].
Around three decades ago, it has been demonstrated that the histamine release can be conditioned and that the dependent mastocytes
reactions can be modulated through psycho-emotional interventions, like hypnosis, the result being the allergic inflammation suppression.
The subintima layer consists of loose and vascularized connective tissue, with spread out fibroblasts, macrophages, mastocytes
, adipose cells, and some elastic fibers that prevent the pleating of the [6-12].
Airway inflammation in asthma is mediated by Th2 cytokines, so the involved cells are basophils, eosinophils, and mastocytes
This protein directly acts on mastocytes
, inducing degranulation, validating a nonspecific urticarial effect of such caterpillars.
BioteCon Therapeutics GmbH (Potsdam, Germany) has patented a hybrid protein contains a protein that binds to a receptor of mastocytes
and basophils and is endocyted by them.
While the cells that differentiate into Th1 promote the immune cellular response by stimulating the production of cytotoxic T cells and increasing the macrophage's activity, Th2 cells contribute to the development of allergic states, inducing the proliferation of eosinophiles and mastocytes
Lymphocytes T (Th1, Th2, CD4+, and CD8+) as well as monocytes, macrophages, dendritic cells, mastocytes
, eosinophils, and fibroblasts are the source of IL-31.
Through the release of specific cytokines from LC, the homing T lymphocytes are activated very rapidly because they are ready on site (in the skin) and they activate B cells with subsequent overproduction of IgE binding not only to LC but also to mastocytes
and basophils, leading to the release of histamine, prostaglandins, and leukotrienes (early phase reaction) 15 to 60 minutes after contact with airborne allergens.
Caption: Figure 3: Total number of cells, mastocytes
, and blood vessels in cutaneous wounds of diabetic rats treated with an ointment of Strychnos pseudoquina extract.