mast cell stabilizers


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Related to mast cell stabilizers: leukotriene modifiers

mast cell stabilizers

Prophylactic drugs used to treat allergic conjunctivitis, vernal conjunctivitis, giant pupillary conjunctivitis, superior limbic keratoconjunctivitis. They act by stabilizing the membranes of mast cells thus preventing the release of histamine. Common agents are sodium cromoglicate (cromolyn sodium), lodoxamide, nedocromil sodium, olopatadine hydrochloride and pemirolast potassium. See antihistamine; hypersensitivity.
References in periodicals archive ?
Because of study heterogeneity, a random-effects model was used and showed that topical mast cell stabilizers relieved symptoms (ocular itching, burning, and lacrimation) 4.9 times more effectively than placebo (95% confidence interval [CI], 2.5-9.6).
3 shows a dose-response comparative study with sodium cromoglycate, a classical mast cell stabilizer. The inhibitory effect of hydroxytyrosol was higher than that obtained with sodium cromoglycate at the same concentration (100 [micro]M) when mast cells were challenged with concanavalin A.
Combination mast cell stabilizers and antihistamines, which combine mechanisms of both antihistaminic and mast cell stabilization in a single drug, are the most recently developed drugs for topical treatment of ocular allergies.
As noted in the previous article (OT, November 12 2010), the ideal management of CLPC involves discontinuation of contact lens wear followed by a four-times-daily (QDS) regimen of a mast cell stabilizer such as sodium cromoglicate.
Tablets, liquids, drops GuaifedPD, EntexLA, Over-the- DuraVENT, Exgest LA, counter Respaire (guaifenesin/ pseudoephedrine) Sinuvent (guaifenesin), Sudafed (pseudoephedrine/ phenylephrine HCL) Mast cell stabilizers. Prevent the release of histamine from mast cells.
For patients who have allergic causes of nasal congestion, there are two general treatment options: (1) avoidance and environmental control and (2) pharmacotherapy with antihistamines, antihistamine/decongestant combinations, corticosteroids, mast cell stabilizers, and immunotherapy.
Mast cell stabilizers Cromolyn (Intal) Nedocromil (Tilade) The corticosteroids and mast cell stabilizers are the two classes of anti-inflammatory agents that are used in asthma.
Topical & injectable corticosteroids, NSAIDs, mast cell stabilizers, histamine receptor blockers, and vasoconstrictors, immune modulators like tacrolimus eye ointment can been used alone or in combination.
Combination mast cell stabilizers and antihistamines are the most recently developed drugs of those available for topical ophthalmic treatment of allergic conjunctivitis.
(22) These mast cell stabilizers should reduce mast cell degranulation in a dose-dependent fashion, (23) and may also reduce migration of white blood cells.
For the analysis, the researchers selected parents of children aged 17 years and younger who had persistent symptoms according to national asthma guidelines and/or used preventive asthma medications (defined as inhaled corticosteroids, mast cell stabilizers, theophylline derivatives, leukotriene modifiers, and combined corticosteroids and longacting [[beta].sub.2]-agonists).