mast cell leukaemia

mast cell leukaemia

An aggressive subtype of acute myeloid leukaemia, which develops in 15% of patients with malignant systemic mastocytosis. 

Clinical findings
Fever, anorexia, weight loss, fatigue, abdominal colic, diarrhoea, pruritus, bone pain, duodenal ulcer, hepatosplenomegaly, lymphadenopathy.
 
Diagnostic criteria
20% neoplastic mast cells in marrow and 10% in peripheral blood cells. If the mast cells comprise < 10% of blood cells, it is called "aleukaemic" mast cell leukaemia.

Prognosis
Poor; therapy buys little time; survival is usually ≤ 6 months.
References in periodicals archive ?
It has also been approved as a monotherapy for three forms of advanced systemic mastocytosis related to haematological neoplasm or mast cell leukaemia.
Mast cell leukaemia is very rare and carries a poor prognosis (10).